朱健

北京大学生命科学学院教授

生命科学联合中心PI

电子邮件: zhua (at) pku (dot) edu (dot) cn；

实验室主页:https://www.bio.pku.edu.cn/homes/Index/news_cont_jl/16/51.html

研究领域：发育、衰老与代谢疾病的调控机制

研究兴趣：

我们以小鼠和果蝇作为模式系统，研究发育、衰老和代谢的分子调控机制，以及它们在干细胞命运决定、形态建成、成体稳态以及营养感知中的关键作用。我们的中长期目标是为衰老、肿瘤、代谢异常等相关疾病开发早期诊断策略和相应的药物靶点。

代表性研究成果：

1. Li, J.*, Zhang, Y.*, Peng, J.*, Yang, W.*, Pan, Y., Xu, Y., Yao, J., Lin, S., Li, Y., Gu, X., Dong, W., Yu, X., Ge, M.#, Liu, M.# and Zhu, A. J.# (2025) A regulator of amino acid sensing links lipid peroxidation and lipid droplet-dependent antioxidant response. Molecular Cell, 85: 3225-3240. doi: 10.1016/j.molcel.2025.08.009

2. Gao, Y.*, Feng, J.*, Zhang, Y, Yi, M., Zhang, L., Yan, Y., Zhu, A. J.# and Liu, M.# (2024) Ehbp1 orchestrates orderly sorting of Wnt/Wingless to the basolateral and apical cell membranes. EMBO Report, 25: 5053-5079. doi: 10.1038/s44319-024-00289-1

3. Wang, Y., Zhou, J., Yang, Q., Li, X., Oiu, Y., Zhang, Y.#, Liu, M.# and Zhu, A. J.# (2024) Therapeutic siRNA targeting PLIN2 ameliorates steatosis, inflammation, and fibrosis in steatotic liver disease models. Journal of Lipid Research, 65: 100635. doi: 10.1016/j.jlr.2024.100635

4. He, T.*, Fan, Y.*, Du, J., Yi, M., Li, Y., Liu, M.# and Zhu, A. J.# (2023) Stuxnet fine-tunes Notch dose during development using a functional Polycomb response element. Development, 150: dev201297. doi: 10.1242/dev.201297

5. Zhang, Y.*, Lin, S.*, Peng, J.*, Liang, X., Yang, Q., Bai, X., Li, Y., Li, J., Dong, W., Wang, Y., Huang, Y., Pei, Y., Guo, J., Zhao, W., Zhang, Z., Liu, M.# and Zhu, A. J.# (2022) Amelioration of hepatic steatosis by dietary essential amino acid-induced ubiquitination. Molecular Cell, 82: 1528-1542. doi: 10.1016/j.molcel.2022.01.021

6. Liu, M.*, Liu, A.*, Wang, J.*, Zhang, Y., Li, Y., Su, Y.# and Zhu, A. J.# (2020) Competition between two phosphatases fine-tunes Hedgehog signaling. Journal of Cell Biology, 220: e202010078. doi: 10.1083/jcb.202010078

7. Du, J.*, Zhang, J.*, He, T., Li, Y., Su, Y., Tie, F., Liu, M., Harte, P. J. and Zhu. A. J.# (2016) Stuxnet facilitates the degradation of Polycomb protein during development. Developmental Cell, 37: 507-519. doi: 10.1016/j.devcel.2016.05.013

8. Liu, M.*, Li, Y.*, Liu, A., Li, R., Su, Y., Du, J., Li, C. and Zhu, A. J.# (2016) The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development. eLife, 5: e17200. doi: 10.7554/eLife.17200

9. Zhang, J., Du, J., Lei, C., Liu, M. and Zhu, A. J.# (2014) UBPY controls the stability of the ESCRT-0 subunit Hrs in development. Development, 141: 1473-1479. doi: 10.1242/dev.099564

10. Su, Y.*, Ospina, J. K.*, Zhang, J.*, Michelson, A., Schoen, A. M. and Zhu, A. J.# (2011) Sequential phosphorylation of Smoothened transduces graded Hedgehog signaling. Science Signaling, 4: ra43. doi: 10.1126/scisignal.2001747