尹航
邮箱：yin_hang@tsinghua.edu.cn
学科方向：化学生物学、新药研发
尹航教授，清华大学药学院教授、原副院长，清华大学第十一届校学术委员会委员、第一届校科技伦理委员会委员。尹航教授团队在本领域一流期刊发表研究论文超过180篇，总引用超2.8万次；并有多项成果已经商业化。尹航教授先后获得中组部国家特聘专家和中国科协海智特聘专家称号、国家自然基金委杰出青年科学基金、北京市卓越青年科学家项目、第二十三届吴阶平-保罗·杨森医学药学奖、第十九届中国药学发展突出成就奖、美国化学学会大卫·W·罗伯特森杰出药物化学家奖、中国药学会科学技术一等奖、美国癌症研究学会格特魯德·B·埃利恩奖等多个奖项。尹航教授现任国际细胞外囊泡协会主席资深顾问，中国细胞外囊泡协会顾问、全国中药标准化技术委员会委员、广东东阳光独立董事、Bioorganic & Medicinal Chemistry Letters主编、Journal of Extracellular Vesicles主编、Cell Chemical Biology等多家国际刊物编委。
实验室主页：http://www.yinlab-tsinghua.cn/
近五年代表性科研论文(H-Index= 65, citations>28,000):
1.Li, H; Zhang, Y; Gao S; *Yin, H. “T cell-intrinsic cGAS-CTCF regulation maintains regulatory T cell development and function”, Cell Rep. 2025, 44,116302.
2.Shen, S.; *Yin, H.“E2-UbR74G Strategy Reveals E2-Specific Ubiquitin Conjugation Profiles in Live Cells”, Nat. Chem. Biol. 2025, 21, 1089-1099.
3.Zhou, Y.; Zhang, X.; *Yin, H.“A Site-Specific Photo-Crosslinking Proteomics Approach Provides Insights into Non-Canonical Pyroptotic Caspase-4 Substrates”, Angew Chem Int Ed Engl. 2025, 12:e202501535.
4.Zhang,Y; Li, H; Hao, Y; Chen, X; Hang Yin*. EGR2 O-GlcNAcylation orchestrates protumoral macrophages development to limit CD8+ T Cell antitumor response. Cell Chemical Biology.2025, 32,809-825.e7 (cover article).
5.Jin, Y.;Sun, G.;Chen, B.;Feng, S.;Tang, M.;Wang, H.;Zhang, Y.;Wang, Y.;An, Y.; Xiao, Y.;Liu, Z.;Liu, P.;Tian, Z.; *Yin, H.;Zhang, S. & Luan, X.“Delivering miR-23b-3p by small extracellular vesicles to promote cell senescence and aberrant lipid metabolism”, BMC Biol. 2025 Feb 11;23(1):41.
6.He, P.;Wen, C.;Zhang, X.;*Yin, H. “Discovery of a Novel CRBN-Recruiting cGAS PROTAC Degrader for the Treatment of Ulcerative Colitis”, J Med Chem. 2025 Mar 13;68(5):5551-5572.
7.Wang, J.; Zhong, X.; Liao, C.; Zhang, Y.; Shen, S.; Zhang, R.; Li, G.; *Yin, H.“MyD88 self-assembles into supramolecular filaments to amplify NF-kB signaling”, Fundamental Res. 2025 Feb.
8.Wang, M.; Chen, H.; Zhang, T.; Zhang, Z.; Xiang, X.; Gao, M.; Guo, Y.; Jiang, S.; Yin, K.; Chen, M.; Huang, J.; Zhong, X.; Ohto, M.; Li, J.; Shimizu, T.; *Yin, H. “Targeting Toll-Like Receptor 7 as a Therapeutic Development Strategy for Systemic Lupus Erythematosus”, Acta Pharm. Sin. B 2024, 14, 4899-4913s (cover article).
9.Kadoch, C.; Sheltzer, J. M.; Yin, H. “The Next Nobel Prize in Chemistry or in Physiology or Medicine”, Cell Chem. Biol. 2024, 31, 1566-1567.
10.Jiang, Y. Y.; Yan, S. T.; Zhang, S. Z.; Wang, M.; Diao, W. M.; Li, J.; Fang, X. M.; *Yin, H. “Discovery of Pyrazolo[1,5-a]pyrimidine Derivatives Targeting TLR4-TLR4∗ Homodimerization via AI-Powered Next-Generation Screening”, Eur. J. Med. Chem. 2024, 280:116945.
11.Tang, Q.; *Yin, H. “Pyridine-Based Small Molecule Inhibitors of SARM1 Alleviate Cell Death Caused by NADase Activity”, Chem. Comm. 2024, 60, 8724-8727.
12.Li, L.; Wang, J.; Zhong, X.; Jiang, Y.; Pei, G.; Yang, X.; Zhang, K.; Shen, S.; Jin, X.; Sun, G.; Su, C.; Chen, S.; *Yin, H. “ADP-Hep-Induced Liquid Phase Condensation of TIFA-TRAF6 Activates ALPK1/TIFA-Dependent Innate Immune Responses”, Research (Washington, D.C.) 2024, 7, e0315.
13.Su, C.; Cheng, T.; Huang, J.; Zhang, T.; *Yin, H. “4-Octyl Itaconate Restricts STING Activation by Blocking Its Palmitoylation”, Cell Rep. 2023, 42, e113040.
14.Jin, X.; Xia, T.; Luo, S.; Zhang, Y.; Xia, Y.; *Yin, H. “Exosomal Lipid PI4P Regulates Small Extracellular Vesicle Secretion by Modulating Intraluminal Vesicle Formation”, J. Extracell. Vesicles 2023, 12, 12319.
15.Liang, J.; *Yin, H. “STAM Transports STING Oligomers into Extracellular Vesicles Down-Regulating the Innate Immune Response”, J. Extracell. Vesicles 2023, 12, e12316.
16.*Yin, H.; Fan, C.; Huang, Y.; *Chen, G. “Innovative Chemistry Research Driven by Medicine”, Fundamental Res. 2023, 3, 479-480.
17.Zhao, X.; Liang, J.; Chen, Z.; Jian, R.; Qian, Y.; Wang, Y.; Guo, Z.; Zhang, W.; Zhang, Y.; Yin, H.; Xia, Y. “sn-1 Specificity of Lysophosphatidylcholine Acyltransferase-1 Revealed by a Mass Spectrometry-Based Assay”, Angew. Chem. Int. Ed. 2023, 62, e202215556.
18.Shi, S.; Yang, X.; Hou, Y.; Jin, X.; Guo, L.; Zhou, Y.; Zhang, C.; *Yin, H. “USP15 Promotes cGAS Activation through Deubiquitylation and Liquid Condensation”, Nucleic Acid Res. 2022, 50, 11093-11108.
19.Li, Y.; Pu, D.; Huang, J.; Zhang, Y.; *Yin, H. “Protein Phosphatase 1 Regulates Phosphorylation of Gasdermin D and Pyroptosis”, Chem. Comm. 2022, 58, 11965-11968.
20.Shi, S.; Yang, X.; Liu, Y.; Li, H.; Chu, H.; Li. G.; *Yin, H. “ZDHHC18 Negatively Regulates cGAS-Mediated Innate Immunity Through Palmitoylation”, EMBO J. 2022, 41, e109272.
21.Yang, X.; Shi, S.; Shen, S.; Li, H.; Su, C.; *Yin, H. “MARCH8 Attenuates cGAS-Mediated Innate Immune Responses Through Ubiquitylation”, Sci. Signal. 2022, 15, eabk3067. (highlighted in “This Week in Science” Science 2022, 376, 593) (cover article).
22.Yang, Y.; Csakai, A.; Jiang, S.; Smith, C.; Tanji, H.; Huang, J.; Jones, T.; Sakaniwa, K; Broadwell, L.; Shi, C.; Soti, S.; Ohto, U.; Fang, Y.; Shen, S.; Deng, F.; Shimizu, T.; *Yin, H. “Tetrasubstituted Imidazoles as Incognito Toll-like Receptor 8 A(nta)gonists”, Nat. Commun. 2021, 12, 4351(featured in the Editor’s Highlights to showcase among the 50 best papers in Organic Chemistry and Chemical Biology).
23.Huang, J.; Yuan, Y.; Zhao, N.; Pu, D.; Tang, Q.; Zhang, S.; Luo, S.; Yang, X.; Wang, N.; Xiao, Y.; Zhang, T.; Liu. Z.; Sakata-Kato, Y.; Hirata, K.; *Jiang, X.; *Kato, N.; *Yan, N.; *Yin, H. “Orthosteric-Allosteric Dual Inhibitors of PfHT1 as Selective Anti-Malarial Agents”, Proc. Natl. Acad. Sci. U. S. A. 2021, 118, e2017749118.
24.Jiang, X.; Yuan, Y.; Huang, J.; Zhang, S.; Luo, S.; Wang, N.; Pu, D.; Zhao, N.; Tang, Q.; Hirata, K.; Yang, X.; Jiao, Y.; Sakata-Kato, Y.; Wu, J.; Yan, C.; Kato, N.; *Yin, H.; *Yan, N. “Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum”, Cell 2020, 183, 258-268.
