魏文胜
电子邮件：wswei (at)pku(dot)edu(dot)cn；
研究领域：基因编辑、功能基因组学、基因及细胞治疗
办公室：北京市海淀区颐和园路5号北京大学综合科研2号楼207室 100871
研究方向:
课题组致力于发展基因编辑技术、新型基因及细胞治疗以及高通量功能基因组学技术，并关注癌症、感染等重大疾病的分子机制研究，为发展高效治疗手段提供新的药物靶点和思路。
代表性科研论文:
1. Guo W, Tang H, Yi Z, Zhang T, Yuan P, Wang C, Ren S, Chang X, Tang W, Ren J, Sun W, Liu J, Yu Y, Lu Z, Shen H, Yi Z, Zhao Y, Tang G, Han J, Zhang W, Liu H, Sun X, Zhang Y, Zhang C, Wu Y, Yang L, Liu Y, Wang Z, Han F, Xu Y, Qu L, Sun X, Wang J*, Ji W*, Chen Y*, and Wei W* (2026) Long-term reversal of Duchenne muscular dystrophy via circular arRNA-guided exon skipping in monkeys and humans. Cell 189, https://doi.org/10.1016/j.cell.2026.05.030.
2. Song D, Liu G, Zhang W, Ren J, Jin X, Sun Y, Yi Z, Qiu S, Tang H, Yi Z, Wang L, Lu Z, Xie J, Liu H, Tang G, Zhang Y, Yu Y, Yuan P, Liu Y, Xiong W, and Wei W* (2026) RNA structure programs endogenous ADAR for precise and efficient editing. Cell 189, https://doi.org/10.1016/j.cell.2026.04.047.
3. Wu Z, Shi J, Lamao Q, Qiu Y, Yang J, Liu Y, Liang F, Sun X, Tang W, Chen C, Yang Q, Wang C, Li Z, Zhang H, Yang Z, Zhang Y, Yi Y, Zheng X, Sun Y, Ma K, Yu L, Yang H, Wang Z, Zheng W, Yang L, Zhang Z, Zhang Y, Wu Z, Wang Y, Wong CCL, Jin M, Yuan P*, Han W*, and Wei W* (2025) Glycan Shielding Enables TCR-Sufficient Allogeneic CAR-T Therapy. Cell 188, 1-18.
4. Zhang XX, Zhang X, Ren J, Li J, Wei XX, Yu Y, Yi Z*, and Wei W* (2025) Precise modelling of mitochondrial diseases using optimized mitoBEs. Nature 639, 735-745.
5. Yi Z, Zhang X, Tang W, Yu Y, Wei X, Zhang X, and Wei W*. (2023) Strand-Selective Base Editing in Mitochondrial DNA using Programmable Deaminases with Targeted Nickase. Nat Biotechnol 42, 498-509.
6. Qu L, Yi Z, Shen Y, Lin L, Chen F, Xu Y, Wu Z, Tang H, Zhang X, Tian F, Wang C, Xiao X, Dong X, Guo L, Lu S, Yang C, Tang C, Yang Y, Yu W, Wang J, Zhou Y, Huang Q, Yisimayi A, Liu S, Huang W, Cao Y, Wang Y, Zhou Z, Peng X, Wang J-W, Xie X, and Wei W*. (2022) Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants. Cell 185, 1728-1744 e1716.
7. Yi Z, Qu L, Tang H, Liu Z, Liu Y, Tian F, Wang C, Zhang X, Feng Z, Yu Y, Yuan P, Yi Z, Zhao Y, and Wei W*. (2022) Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo. Nat Biotechnol 40(6): 946-955.
8. Qu L, Yi Z, Zhu S, Wang C, Cao Z, Zhou Z, Yuan P, Yu Y, Tian F, Liu Z, Bao Y, Zhao Y, Wei W*. (2019) Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs. Nat Biotechnol 37, 1059-1069.
9. Zhao X, Zhang G, Chen X, Dai L, Qu X, Li S, Liu S, Song H, Gao Z, Yuan P, Liu Z, Li C, Shang Z, Li Y, Zhang M, Qi J, Wang H, Du N, Wu Y, Bi Y, Gao S, Shi Y, Yan J, Zhang Y, Xie Z*, Wei W* and Gao GF*. (2019) Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B. Cell 177(6), 1553-1565.
10. Zhou Y, Zhu S, Cai C, Yuan P, Li C, Huang Y and Wei W*. (2014) High-throughput Screening of a CRISPR/Cas Library for Functional Genomics in Human Cells. Nature 509(7501): 487-91.
