吴励
电子邮件：wuli@tsinghua.edu.cn
电话：+86-10-62794835
研究领域：
1固有免疫细胞发育分化的分子调控
2眼免疫系统的稳态调节及相关疾病的免疫学机制研究
3固有免疫细胞调控肿瘤免疫应答的机制研究
代表性科研论文:
1. Liu JC,Ma J,Yao JY,Y Z,Wang YH,Yang CY,Li X, Xing NZ,Zhu YP,Zhang JH,Wu L. High-resolution transcriptome atlas of bladder cancer highlights the functional myeloid subsets in modulating immune microenvironment. eBioMedicine 2025 Volume117
2. Shen XY , Li XG, Guo TT, Wu T, Lv JY , He ZM , Luo MC , Zhu XY , Tian YJ, Lai WL , Dong C , Hu XY and Wu L.TRIM33 plays a critical role in regulating dendritic cell differentiation and homeostasis by modulating Irf8 and Bcl2l11 transcription.Cellular & Molecular Immunology; 2024 https://doi.org/10.1038/s41423-024-01179-1.
3. Zhou HB and Wu L.Cancer cells reprogrammed into dendritic cells in vivo promote antitumor immunity.science.2024,VOL 386 ISSUE 6719 10.1126/science.ads6761.
4. Tian YJ, Guo XH, Wu T, Fei KY, Wu L. Identification of a novel cDC2-committed progenitors within mouse common dendritic cell progenitor population. Protein & Cell, 2022, https://doi.org/10.1007/s13238-021-00902-2.
5. Proietto AI, Mittag D, Roberts AW, Sprigg N,Wu L. The equivalents of human blood and spleen dendritic cell subtypes can be generated in vitro from human CD34+ stem cells in the presence of fms-like tyrosine kinase 3 ligand and thrombopoietin. Cell & Mol. Immunol. 2012,9, 446–454. SCI.
6. Zhan YF,Wu L. Functional regulation of monocyte-derived dendritic cells by microRNAs.Protein & Cell. 2012, 3(7): 497–507. SCI.
7. Sathe P, Vremec D, Wu L, Corcoran L, Shortman K. Convergent differentiation: myeloid and lymphoid pathways to murine plasmacytoid dendritic cells. Blood. 2012. Oct 10. doi:10.1182/blood-2012-02-413336.
8. Carotta S, Dakic A, D’Amico A, Pang SHM, Greig KT, Nutt SL,Wu L. The Transcription Factor PU.1 Controls Dendritic Cell Development and Flt3 Cytokine Receptor Expression in a Dose Dependent Manner. Immunity 28:628-41, 2010
9. Proietto AI, van Dommelen S, Zhou P, Rizzitelli A, D'Amico A, Steptoe RJ, Naik SH, Lahoud MH, Liu Y, Zheng P, Shortman K and Wu L. Dendritic cells in the thymus contribute to T-regulatory cell induction. Proceedings of The National Academy of Sciences USA 105:19869-19874, 2008.
10. Naik SH, Sathe P, Park H-Y, Metcalf D, Anna I. Proietto AI, Dakic A, Carotta S, O’Keeffe M, Bahlo M, Papenfuss A, Kwak J-Y, Wu L, Shortman K. Development of plasmacytoid and conventional dendritic cell subtypes from single in vitro and in vivo-derived precursors. Nature Immunology 8:1217, 2007.
11. Wu L,Liu YJ. The Development of Dendritic Cell Lineages. Immunity. 26:741-750. 2007.
12. Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, Wu L, Lindeman GJ, & Visvader JE. Generation of a functional mammary gland from a single stem cell. Nature 439:84-88. 2006.
13. Wu L, D’Amico A, Winkel K.D, Suter M, Lo D, Shortman K. RelB is essential for the development of Myeloid-related CD8a- dendritic cells but not of lymphoid-related CD8a+ dendritic cells. Immunity, 9:839-847, 1998.
14. Ardavin C, Wu L, Li C-L, Shortman K. Thymic dendritic cells and T cells develop simultaneously within the thymus from a common precursor population. Nature 362: 761-763, 1993.
15. Wu L, Scollay R, Egerton M, Pearse M, Spangrude GJ, Shortman K. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature 349: 71-74, 1991.
