宋艳
北京大学生命科学学院学院研究员
北大-清华生命科学联合中心PI
电子邮件:yan.song@pku.edu.cn
实验室主页:http://www.yansonglab.org
研究领域：
脑发育中细胞命运决策、细胞记忆传承及相关神经发育疾病机理研究
研究兴趣：
大脑是我们人体内最为复杂的器官。作为我们神经系统的高级中枢，人类大脑由上千亿个神经元、大致相同数量的非神经元细胞和数万亿个神经连接组成，从组装到运行都异常复杂和精妙。这些神经细胞不但数量庞大、种类繁多，还需在合适的时间和地点产生，才可能建立正确的神经连接，进而支持我们诸如思维、认知、学习、语言等高级神经活动。大脑发育异常可能导致儿童脑瘤、小脑症、自闭症等诸多神经发育疾病。深入解析神经发育的分子调控机理是防治相关神经发育疾病的基础和关键。课题组通过将新开发的BISMIB 多组学技术与果蝇遗传学、小鼠遗传学、液-液相分离、全脑亚细胞结构活体成像、细胞生物学及生物化学等手段相结合，现阶段特别感兴趣的科学问题包括：1. 细胞命运记忆传承：脑发育过程中细胞如何在有丝分裂后精确“维持”或选择性“删除”其细胞命运记忆？2. 专属基因表达程序：大脑作为人体最复杂的器官，其发育过程是否有其独特的基因表达程序？这个专属程序如何运行，其运行错误如何导致相关神经发育疾病的发生？3. 神经发育时程解码：神经发育的时程信号如何被及时、精确读取并转换成细胞命运决策事件，确保神经元多样性的产生和维持？
实验室更多信息请访问: http://yansonglab.org
Journal of Cell Biology 杂志 People & Ideas 专栏人物专访: https://doi.org/10.1083/jcb.201912056
代表性研究成果：
Shen D.#, Chu J.#, Zhou X.#, Lan Z., Zhang R., Wang S., Tang H., Wang Y., Hu C., Li Z.* and Song Y.* (2026) Temporal neuronal differentiation programs safeguard neuronal diversity. Proc. Natl. Acad. Sci. USA, doi.org/10.1073/pnas.2527895123
Shen Y., Liu K., Liu J., Shen J., Ye T., Zhao R., Zhang R. and Song Y.* (2025) TBP bookmarks and preserves neural stem cell fate memory by orchestrating local chromatin architecture. Molecular Cell, 85(2):413-429
Zhang R.#, Liu J.#, Zhang Z., Chen Z., Wang T., Shen Y., Lan Z., Chu J., Tang H., Zhang X. and Song Y.* (2025) Dual mitotic bookmarking by GAF and H3K27ac orchestrates differential propagation of cell fate memory in neural development. Nature Communications, doi.org/10.1038/s41467-025-62974-6
Liu X.#, Shen J.#, Xie L., Wei Z., Wong C., Li Y., Zheng X., Li P. and Song Y.* (2020) Mitotic implantation of a transcription factor via phase separation drives terminal neuronal differentiation. Developmental Cell, 52(3), 277-293; doi.org/10.1016/j.devcel.2019.11.019 [Featured Article].
Liu K., Shen D., Shen J., Gao S.M., Li B., Wong C., Feng W. and Song Y.* (2017) The super elongation complex drives neural stem cell fate commitment. Developmental Cell, 40(6), 537-551 [Cover article].
Li B.#, Wong C.#, Gao S.M., Zhang R., Sun R., Li Y. and Song Y.* (2018) The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking. Elife 2018;7;e38181 DOI: 10.7554/eLife.38181
Xu K., Liu X., Wang Y., Wong C. and Song Y.* (2018) Temporospatial induction of homeodomain gene cut dictates natural lineage reprogramming. Elife 2018;7:e33934 DOI: 10.7554/eLife.33934
Shen Y., Liu J. and Song Y.* (2025) Protocol for identifying genomic binding sites of mitotic bookmarkers in Drosophila neural stem cells and cultured mammalian cells. STAR Protocols, doi.org/10.1016/j.xpro.2025.103858
He R.#, Dong T.#, Chu J.#, Wang Y., Wang X., Song Y.* and Sun Y.* (2024). Phaser-Trim: a phase separation based genetically-encoded reporter for H3K9 trimethylation in living cells. Analytical Chemistry, doi: 10.1021/acs.analchem.4c00992.
Song Y.* (2022) It takes two to tango: The dance of cell fate specification. Developmental Biology, 490:125.
