石彦
电子邮件: yanshiemail@tsinghua.edu.cn
电话：+86-10-62797488
科研方向
从事免疫学方向的研究，主要通过单细胞力谱仪和高分辨单细胞成像技术分析树突状细胞的激活过程。于2012年从加拿大回国任职，担任清华大学终身教授。早期发现尿酸是哺乳动物的免疫危险因子。
近年来的主要研究成果:
1. 发现了树突状细胞表面脂质对外界的固态物质反应。这个效应是固态颗粒免疫激活或者佐剂作用的基础。申请人发现力学作用所产生的免疫调节可以延伸到细胞与细胞之间的相互作用。在调节性T细胞和树突状细胞接触中，强烈的粘合作用导致后者细胞骨架极化，形成免疫抑制。
2. 肠道菌落和外界免疫系统发育之间的关系: 近年来的实验室结果显示，新生小鼠的肠道中的真菌可以释放生物物质，刺激肠道的CD103阳性的树突状细胞，这些细胞向外周淋巴结转移，并带去视黄酸，诱导这些组织的发育。
代表性科研论文
1.Wang X, Geng S, Meng J, Kang N, Liu X, Xu Y, Lyu H, Xu Y, Xu X, Song X. Foxp3-mediated blockage of ryanodine receptor 2 underlies contact-based suppression by regulatory T cells. Journal of Clinical Investigation. 2023;133(24):e163470.
2.Tong D, Zhang L, Ning F, Xu Y, Hu X, Shi Y. Contact-dependent delivery of IL-2 by dendritic cells to CD4 T cells in the contraction phase promotes their long-term survival. Protein & Cell. 2020;11(2):108-23.
3.Song D, Meng J, Cheng J, Fan Z, Chen P, Ruan H, Tu Z, Kang N, Li N, Xu Y. Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution. Nature microbiology. 2019;4(1):97-111.
4.Mu L, Tu Z, Miao L, Ruan H, Kang N, Hei Y, Chen J, Wei W, Gong F, Wang B, Du Y, Ma G, Amerein MW, Xia T*, Shi Y*. A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing. Nat Commun. 2018 9(1):4259.
5.Zhang Y, Rong H, Zhang FX, Wu K, Mu L, Meng J, Xiao B, Zamponi GW, Shi Y. A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome. Cell Rep. 2018 24(9):2356-69 e5.
6.Xia Y, Xie Y, Yu Z, Xiao H, Jiang G, Zhou X, Yang Y, Li X, Zhao M, Li L, Zheng M, Han S, Zong Z, Meng X, Deng H, Ye H, Fa Y, Wu H, Oldfield E, Hu X, Liu W*, Shi Y*, Zhang Y*. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Sep 20.
7.Zhang Z, Li J, Zheng W, Zhao G, Zhang H, Wang X, Guo Y, Qin C, Shi Y. Peripheral lymphoid volume expansion and maintenance are controlled by gut microbiota via RALDH+ dendritic cells. Immunity. 2016;44(2):330-42.
8.Flach TL, Ng G, Hari A, Desrosiers MD, Zhang P, Ward SM, Seamone ME, Vilaysane A, Mucsi AD, Fong Y. Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity. Nature medicine. 2011;17(4):479-87.
9.Ng G, Sharma K, Ward SM, Desrosiers MD, Stephens LA, Schoel WM, Li T, Lowell CA, Ling C-C, Amrein MW,Shi Y. Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity. 2008;29(5):807-18.
10.Shi Y, Evans JE, Rock KL. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature. 2003;425(6957):516-21.
