乔杰
北京大学第三医院研究员/教授
生命科学联合中心PI
电子邮件:jie.qiao（AT）263.net
实验室主页：https://sklffp.puh3.net.cn/
研究领域：配子及胚胎发育机制研究、生殖障碍性疾病机制研究
研究兴趣:
生命起源始于精子与卵子的精准相遇与结合，配子及胚胎发育机制则是生殖医学与生命科学的核心命题。通过多学科技术交叉融合探究生命规律，深入解析精、卵发生和成熟以及胚胎发育的关键机制，是守护生殖健康、筑牢生命起源防线的重要科学支撑。进而，将基础研究成果应用于临床胚胎着床前遗传学诊断新方法研发，揭示疑难不孕症发病机制，优化辅助生殖技术方法等，更是提高疑难不孕患者治疗成功率的重要支撑。
代表性研究成果:
1. Zhou, S., Li, M., Wang, P., Guo, C., Zhang, J., Luo, X., Fan, Y. C., Chen, E. Q., Qi, X., Chen, J., Ye, L., Yuan, H. Y., Yin, W. B., Wang, K., Zheng, M. H., Pang, Y., Qiao, J*., & Jiang, C. (2025). A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite-CerS6-ceramide axis. Science (New York, N.Y.), 388(6746), eadp5540.
2. Lu, Y., Qin, M., He, Q., Hua, L., Qi, X., Yang, M., Guo, Q., Liu, X., Zhang, Z., Xu, F., Ding, L., Wu, Y., Zhang, C., Zhai, F., Liu, Q., Li, J., Yuan, P., Shi, X., Wang, X., Zhao, C., … Qiao, J*. (2024). How the extra X chromosome impairs the development of male fetal germ cells. Nature, 10.1038/s41586-024-08104-6.
3. Wang, Y., Li, R., Yang, R., Zheng, D., Zeng, L., Lian, Y., Zhu, Y., Zhao, J., Liang, X., Li, W., Liu, J., Tang, L., Cao, Y., Hao, G., Wang, H., Zhang, H., Wang, R., Mol, B. W., Huang, H., & Qiao, J*. (2024). Intracytoplasmic sperm injection versus conventional in-vitro fertilisation for couples with infertility with non-severe male factor: a multicentre, open-label, randomised controlled trial. Lancet (London, England), 403(10430), 924–934.
4. Wang, K. , Zhang, Z. W. , Hang, J. , Liu, J. , Guo, F. S. , Ding, Y. , Li, M. , Nie, Q. X. , Lin, J. , Zhuo, Y. Y. , Sun, L. L. , Luo, X. , Zhong, Q. H. , Ye, C. , Yun, C. Y. , Zhang, Y. , Wang, J. , Bao, R. , Pang, Y. L. , Wang, G. , Gonzalez, F. J. , Lei, X. G. , Qiao, J*. , & Jiang, C. T. Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target. SCIENCE, 2023, 381(6657): 501.
5. Zhang, P. , Dong, J. , Fan, X. Y. , Yong, J. , Yang, M. , Liu, Y. S. , Zhang, X. , Lv, L. W. , Wen, L. , Qiao, J*. , Tang, F. C. , & Zhou, Y. S. Characterization of mesenchymal stem cells in human fetal bone marrow by single-cell transcriptomic and functional analysis. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 8(1).
6. Dang, Y. J. , Zhu, L. , Yuan, P. , Liu, Q. , Guo, Q. Y. , Chen, X. , Gao, S. X. , Liu, X. , Ji, S. S. , Yuan, Y. F. , Lian, Y. , Li, R. , Yan, L. Y. , Wong, C. , & Qiao, J*. Functional profiling of stage-specific proteome and translational transition across human pre-implantation embryo development at a single-cell resolution. CELL DISCOVERY, 2023, 9(1).
7. Wang H, Gao H, Chi H, Zeng L, Xiao W, Wang Y, Li R, Liu P, Wang C, Tian Q, Zhou Z, Yang J, Liu Y, Wei R, Mol BWJ, Hong T, Qiao J* (2017). Effect of Levothyroxine on Miscarriage Among Women With Normal Thyroid Function and Thyroid Autoimmunity Undergoing In Vitro Fertilization and Embryo Transfer. JAMA.318(22):2190-2198
8. Guo F, Yan L, Guo H, Li L, Hu B, Zhao Y, Yong J, Hu Y, Wang X, Wei Y, Wang W, Li R, Yan J, Zhi X, Zhang Y, Jin H, Zhang W, Hou Y, Zhu P, Li J, Zhang L, Liu S, Ren Y, Zhu X, Wen L, Gao Y, Tang F * and Qiao J * (2015). The transcriptome and DNA methylome landscapes of human primordial germ cells. Cell. 161(6):1437-52.
9. Guo HS, Zhu P, Yan LY, Li R, Hu BQ, Lian Y, Yan J, Ren XL, Lin SL, Li JS, Jin XH, Shi XD, Liu P, Wang XY, Wang W, Wei Y , Li XL, Guo F, Wu XL, Fan XY, Yong J, Wen L, Xie S X, Tang FC *, Qiao J* (2014). The DNA methylation landscape of human early embryos. Nature. 511:606–610.
10. Hou Y, Fan W, Yan L, Li R, Lian Y, Huang J, Li J, Xu L, Tang F*, Xie XS*, Qiao J* (2013). Genome analyses of single human oocytes. Cell. 155:1492-1506.
