孟安明
邮件：mengam(at)mail(dot)tsinghua(dot)edu(dot)cn
主要科研领域与方向：
实验室主要以斑马鱼和小鼠为模式动物，研究脊椎动物胚胎早期发育，包括胚胎卵裂期和早期囊胚的细胞命运、胚层诱导和分化、背-腹轴和头-尾轴形成的重要调控，并揭示其作用机制。
代表性科研论文
1.Sun K, Liu X, Xu R, Liu C, Meng A*, Lan X*. 2024. Mapping the chromatin accessibility landscape of zebrafish embryogenesis at single-cell resolution by SPATAC-seq. Nature Cell Biology, 26(7):1187-1199.
2.Shen W, Gong B, Xing C, Zhang L, Sun J, Chen Y, Yang C, Yan L, Chen L, Yao L, Li G, Deng H, Wu X, Meng A*. 2022. Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation. Cell, 185(26):4954-4970.
3.Jin H, Han Y, Wang H, Li JXH, Shen W, Zhang L, Chen L, Jia S, Yuan P, Chen H, Meng A*. 2022. The second polar body contributes to the fate asymmetry in the mouse embryo. National Science Review, 9(7).
4.Jia S, Meng A*. 2021. TGFβ family signaling and development. Development, 148(5).
5.Chen L, Xu W, Liu K, Jiang Z, Han Y, Jin H, Zhang L, Shen W, Jia S, Sun Q, Meng A*. 2021. 5' Half of specific tRNAs feeds back to promote corresponding tRNA gene transcription in vertebrate embryos. Science Advances, 7(47).
6.Zhang L, Chen L, Chen J, Shen W, Meng A*. 2020. Mini-III RNase-based dual-color system for in vivo mRNA tracking. Development, 147(22).
7.Yan L, Chen J, Zhu X, Sun J, Wu X, Shen W, Zhang W, Tao Q*, Meng A*. 2018. Maternal Huluwa dictates the embryonic body axis through β-catenin in vertebrates. Science, 362(6417).
8.Sun J, Yan L, Shen W, Meng A*. 2018. Maternal Ybx1 safeguards zebrafish oocyte maturation and maternal-to-zygotic transition by repressing global translation. Development, 145(19).
9.Zhang J, Jiang Z, Liu X, Meng A*. 2016. Eph-ephrin signaling maintains the boundary dorsal forerunner cell cluster during morphogenesis of the zebrafish embryonic left-right organizer. Development, 143(14):2603-2615.
10.Xue Y, Zheng XD, Huang L, Xu P, Ma Y, Min Z, Tao Q, Tao Y*, Meng A*. 2014. Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development. Nature Communications, 5:3766.
