刘志华
副教授，博导
联系方式：
邮箱：zhihualiu@mail.tsinghua.edu.cn
电话：+86-10-64888004
2020年至今 副教授，清华大学医学院
2012年至2019年 研究员，中国科学院生物物理研究所
2006年至2011年 博士后，美国国立健康研究院
1999年至2005年 博士，哈佛大学，生物化学专业
1995年至1999年 学士，北京大学，生命科学专业
主要科研领域与方向：
实验室致力于揭示生命体内外复杂的细胞间通讯网络。数以百亿计的肠道菌在我们机体的作用是什么？巨噬细胞如何感知实质细胞的代谢活动进而调控组织微环境？我们的研究围绕这两个看着毫不相干但却存在内在关联的问题开展。我们以菌群信号及实质细胞的代谢信号为研究对象，解析肠道稳态的维持机制，解析组织中巨噬细胞与实质细胞的协同互作，探索不同生命实体（菌群 vs. 宿主细胞，巨噬细胞 vs. 实质细胞）之间如何通过化学信号进行“交流”，以维持整体的稳态与健康，揭示了生命作为一个复杂系统的底层逻辑。
近期代表性论文（*通讯作者，#共同第一作者）：
1.Yinghui Li, Xingchen Liu, Xue Sun, Hui Li, Shige Wang, Wotu Tian, Chen Xiang, Xuyuan Zhang, Jiajia Zheng, Haifang Wang, Liguo Zhang, Li Cao*, Catherine CL Wong* and Zhihua Liu*(2024). Gut dysbiosis impairs intestinal renewal and lipid absorption in Scarb2 deficiency-associated neurodegeneration. Protein & Cell, 15(11):818-839.
2.Chengye Zhang, Chen Xiang, Kaichen Zhou, Xingchen Liu, Guofeng Qiao, Yabo Zhao, Kemeng Dong, Ke Sun, and Zhihua Liu*(2024). Intestinal Lysozyme1 Deficiency Alters Microbiota Composition and Impacts Host Metabolism Through the Emergence of NAD+-Secreting ASTB Qing110 Bacteria. mSystems, 9(3):e0121423.
3.Haiyuan Shen, Liangliang Zhou, Hao Zhang, Yuanru Yang, Ling Jiang, Dongqing Wu, Hang Shu, Hejiao Zhang, Linxi Xie, Kaichen Zhou, Chen Cheng, Lei Yang, Jiali Jiang, Siya Wang, Yiran Han, Jiayi Zhu, Long Xu, Zhihua Liu*, Hua Wang*, and Shi Yin*（2024）. Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification. Cell Host & Microbe, 32(8):1331-1346.e6.
4.Dongju Wang, Haifang Wang, Wei Wan, Zihui Zhu, Takami Sho, Yi Zheng, Xing Zhang, Longyu Dou, Qiang Ding, Li Yu* & Zhihua Liu*(2024). Engineered Migrasomes: A Robust, Thermally Stable Vaccination Platform. eLife accepted.
5.Lingjuan Jiang, Mengmeng Shang, Shengnan Yu, Yudong Liu, Hui Zhang, Yangzhong Zhou, Min Wang, Tingting Wang, Hui Li, Zhihua Liu*and Xuan Zhang*(2023). A high-fiber diet synergizes with Prevotella copri and exacerbates rheumatoid arthritis. Cell Mol Immunol, 19(12):1414-1424.
6.Dong Wu, Kaichen Zhou, Meng Xiao, Zhihua Liu*, Shuyang Zhang*(2022). Differences in intestinal microbiome are associated with the mortality of COVID-19 patients in intensive care units. Science China Life sciences, 65(5):1040-1042.
7.Chen Xiang, Peihua Chen, Qin Zhang, Yinghui Li, Ying Pan, Wenchun Xie, Jianyuan Sun, Zhihua Liu*(2021). Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells. iScience, 24(8):102849.
8.Haifang Wang, Xueying Shen, Xiaojiao Zheng, Ying Pan, Qin Zhang, Zhihua Liu*(2021). Intestinal lysozyme releases Nod2 ligand(s) to promote the intestinal mucosal adjuvant activity of cholera toxin. Science China Life sciences, 64(10):1720-1731.
9.Jiaying Yu, Xin He, Aihua Wei, Teng Liu, Qin Zhang, Ying Pan, Zhenhua Hao, Lin Yang, Yefeng Yuan, Zhao Zhang, Chang Zhang, Chanjuan Hao, Zhihua Liu*, Wei Li*(2020). HPS1 Regulates the Maturation of Large Dense Core Vesicles and Lysozyme Secretion in Paneth Cells. Frontiers in immunology, 11:560110.
10.Qin Zhang, Ying Pan, Benhua Zeng, Xiaojiao Zheng, Haifang Wang, Xueying Shen, Hui Li, Qian Jiang, Jiaxu Zhao, Zhuo-Xian Meng, Pingping Li, Zhengjun Chen, Hong Wei* and Zhihua Liu*(2019). Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells, Cell Research, 29(7):516-532.
