罗佗平

北京大学化学与分子工程学院教授

北大-清华生命科学联合中心PI

电子邮件: tuopingluo(at)pku(dot)edu(dot)cn ；

实验室主页: http://www.chem.pku.edu.cn/luotp/

研究领域：有机化学、化学生物学

研究兴趣:

致力于发展和应用有机化学的新反应与新方法，并以此为核心工具推动生命科学研究的发展，尤其聚焦于化学生物学及创新药物相关领域。围绕这一总体目标，我们从两个互补方向开展研究：一方面，通过广泛的跨学科合作，开发高效的小分子抑制剂、激动剂、化学探针及基于化学原理的生物研究技术；另一方面，对现有化学反应体系提出新的科学问题，探索更高效、更普适的合成策略与反应模式。

代表性科研论文:

1. “Total Synthesis of (+)-Resiniferatoxin via a Pyridinium Salt Photorearrangement” Yu, H.; Kong, L.; Qin, J.; Wang, Z.; Luo, T.* J. Am. Chem. Soc. 2025, 147, 42164−42169.

2. “Desulfurative Modification of Cysteine Residues in Peptides and Proteins via the Installation and Photoexcitation of Thieno[2,3-c]-Pyrroles” Chen, Z.^†; Wang, W.^†; Chen, B.; Chen, S.-C.; Aoken, A.; Wu, F.; Zeng, G.; Luo, T.* Chem. Sci. 2025, 16, 22091−22100. (^†co-first author)

3. “Synthesis of (+)-Saxitoxin Facilitated by a Chiral Auxiliary for Photocycloadditions Involving Alkenylboronate Esters” Jiao, Y.; Liu, J.; Mao, W.; Fang, R.; Xia, T.; Luo, T.* J. Am. Chem. Soc. 2025, 147, 9091−9097.

4. “Enantioselective Total Syntheses of (+)-Kobusine, (+)-Spirasine IX and the Purported Structure of (+)-Orgetine: Strategic Use of C–H Bonds” Deng, M.; Wu, F.; Liu, T.; Jiang, Z.; Luo, T.* J. Am. Chem. Soc. 2025, 147, 8132−8137.

5. “Photoaffinity Labeling Coupled with Proteomics Identify PDI-ADAM17 Module is Targeted by (–)-Vinigrol to Induce TNFR1 Shedding and Ameliorate Rheumatoid Arthritis in Mice” Zhu, Y.^†; Wang, L.^†; Li, J.^†; Zhao, Y.; Yu, X.; Liu, P.; Deng, X.; Liu, J.; Yang, F.; Zhang, Y.; Yu, J.; Lai, L.; Wang, C.; Li, Z.*; Wang, L.*; Luo, T.* Cell Chem. Biol. 2024, 31, 452−464. (^†co-first author)

6. “Enantioselective Total Synthesis of (–)-Zygadenine” Guo, Y.; Lu, J.-T.; Fang, R.; Jiao, Y.; Liu, J.; Luo, T.* J. Am. Chem. Soc. 2023, 145, 20202−20207.

7. “Total Synthesis of (+)-Mutilin: A Transannular [2+2] Cycloaddition/Fragmentation Approach” Chen, H.; Li, Z.; Shao, P.; Yuan, H.; Chen, S.-C.; Luo, T.* J. Am. Chem. Soc. 2022, 144, 15462−15467.

8. “Enantioselective Total Syntheses of Grayanane Diterpenoids: (–)-Grayanotoxin III, (+)-Principinol E, and (–)-Rhodomollein XX” Kong, L.; Yu, H.; Deng, M.; Wu, F.; Jiang, Z.; Luo, T.* J. Am. Chem. Soc. 2022, 144, 5268−5273.

9. “Dealkenylative Ni-Catalyzed Cross-Coupling Enabled by Tetrazine and Photoexcitation” Chen, S.-C.; Zhu, Q.; Cao, Y.; Li, C.; Guo, Y.; Kong, L.; Che, J.; Guo, Z.; Chen, H.; Zhang, N.; Fang, X.; Lu, J.-T.; Luo, T.* J. Am. Chem. Soc. 2021, 143, 14046−14052.

10. “Total Synthesis of (–)-Batrachotoxinin A: A Local-Desymmetrization Approach” Guo, Y.; Guo, Z.; Lu, J.-T.; Fang, R.; Chen, S.-C.; Luo, T.* J. Am. Chem. Soc. 2020, 142, 3675−3679.