江鹏，博士

清华大学生命学院研究员，生命科学联合中心PI

邮箱：jiang-lab@tsinghua.edu.cn

研究方向

为肿瘤和免疫代谢，特别关注代谢物信号。先后发现了1）包括尿素循环和多胺合成代谢途径等代谢途径的异常改变，以及胆碱代谢和一碳代谢对肿瘤，特别是携带p53缺失或突变的恶性肿瘤的增殖和存活的关键作用；2）特定代谢物（如延胡索酸，瓜氨酸等）代谢感知和信号功能对免疫细胞免疫应答和抗肿瘤能力的影响；以及3）决定细胞命运分化（如GC B细胞分化和T细胞耗竭）的决定因素。

代表性论文：

1.Xia W^#, Mao Y^#, Xia Z^#, Cheng J, Jiang P*. (2025). Metabolic remodelling produces fumarate via the aspartate-argininosuccinate shunt in macrophages as an antiviral defence. Nature Microbiology. 10(5):1115-1129.

2.Cheng J^#, Xiao Y^#, Peng T^#, Zhang Z^#, Qin Y^#, Wang Y, Shi J, Yan J, Zhao Z, Zheng L, He Z, Wang J, Zhang Z*, Li C*, Zhu H*, Jiang P*. (2025). ETV7 limits the antiviral and antitumor efficacy of CD8+ T cells by diverting their fate toward exhaustion. Nature Cancer. 6(2):338-356.

3.Wu J^#, Zhou J^#, Li G^#, Sun X, Xiang C, Chen H, Jiang P*. (2024). Metabolic determinants of germinal center B cell formation and responses. Nat Chemical Biology. 21(3):371-382.

4.Xia W, Jiang P*. (2024). p53 promotes antiviral innate immunity by driving hexosamine metabolism. Cell Reports. 43(2):113724.

5.Xu X, Wang J, Xu L, Li P*, Jiang P*. (2024). p53 suppresses lipid droplet-fueled tumorigenesis through phosphatidylcholine. J Clin Invest. 134(4):e171788.

6.Chen T^#, Xie S^#, Cheng J, Zhao Q, Wu H*, Jiang P*, Du W*. (2024). AKT1 phosphorylation of cytoplasmic ME2 induces a metabolic switch to glycolysis for tumorigenesis. Nat Communs. 15(1):686.

7.Cheng J^#, Yan J^#, Liu Y#, Shi J^#, Wang H, Zhou H, Zhou Y, Zhang T, Zhao L, Meng X, Gong H, Zhang X*, Zhu H*, Jiang P*. (2023). Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment. Cell Metabolism. 35(6):961-978.

8.Cheng, J^#, Liu, Y^#, Yan, J^#, Zhao L, Zhou Y, Shen X, Y, Chen Y, Meng X, Zhang X* & Jiang P*. (2022). Fumarate suppresses B-cell activation and function through direct inactivation of LYN. Nature Chemical Biology. 18(9):954-962.

9.Zhao M^#, Yao P^#, Mao Y^#, Wu J^#, Wang W, Geng C, Cheng J, Du W * and Jiang P*. (2022). Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate. Nature Metabolism. 4(2):225-238.

10.Mao Y, Shi D, Li G, Jiang P*. (2022). Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses. Molecular Cell. 82(3):527-541.

11.Li G^#, Wu J^#, Li L, Jiang P*. (2021). p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage. Proc Natl Acad Sci U S A. 118(28):e2019822118.

12.Wu J^#, Li G^#, Li L, Li D, Dong Z, Jiang P*. (2021). Asparagine enhances LCK signalling to potentiate CD8⁺ T cell-activation and anti-tumour responses. Nature Cell Biology, 23(1):75-86.

13.Deng L, Yao P, Li L, Ji F, Zhao S, Xu C, Lan X, Jiang P*. (2020). p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival. Nature Communications, 11(1):1755.

14.Li L, Mao Y, Zhao L, Li L, Wu J, Zhao M, Du W, Yu L, Jiang P*. p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis. Nature. (2019) 567(7747):253-256.

15.Li L^#, Li L^#, Li W, Chen T, Bin Zou, Zhao L, Wang H, Wang X, Xu L, Liu X, Wang D, Li B, Mak TW, Du W*, Yang X*, Jiang P*. TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation. Nature Communs. (2018), Nov 8; 9(1):4683.

16.Du W^#, Jiang P^#, Mancuso A, Stonestrom A, Brewer M, Minn AJ, Mak TW, Wu M* and Yang X*. TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nature Cell Biology. (2013), Aug. 15, 991–1000.

17.Jiang P^#, Du W^#, Mancuso A, Wellen KE, Yang X*. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature. (2013), Jan. 493: 689-693.  

18.Jiang P^#, Du W^#, Wang X, Mancuso A, Gao X, Wu M* and Yang X*. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nature Cell Biology. (2011) Mar.13: 310-316.

应邀综述和评论

19.Zhou J^#, Sun X^#, Jiang P*. (2025). The emerging roles of the urea cycle in tumor microenvironment and therapies. Trends in Cancer. 12:S2405-8033(25)00205-5.

20.Cheng J^#, *, Xiao Y^#, Jiang P*. (2025). Fumarate integrates metabolism and immunity in diseases. Trends in Endocrinol Metabolism. 16: S1043-2760(25)00051-7.

21.Jiang P*. A glycolytic metabolite that drives BRCA2 haploinsufficiency. Cell. (2024) Apr 25;187(9):2124-2126. Invited preview.

22.Mao Y^#, Xia Z^#, Xia W^#, Jiang P*. (2024). Metabolic reprogramming, sensing, and cancer therapy. Cell Reports. 43(12):115064.

23.Wu J^#, Sun X^#, Jiang P*. (2024). Metabolism-inflammasome crosstalk shapes innate and adaptive immunity. Cell Chemical Biology. 31(5):884-903.