何跃辉
Email: yhhe（at）pku（dot）edu（dot）cn
Tel: +86-10-62755866
研究方向
植物环境表观遗传学 (plant environmental epigenetics)。利用分子、生化、遗传及组学等手段，揭示环境信号包括光周期和冬季低温调控植物开花时间（flowering time）的分子与表观遗传机制。种子植物历经营养生长后转换至生殖生长，其转换时机（即成花转变时间或开花时间）受多种内在因子（如年龄、激素等）与外源环境因素（如日照长度变化、温度等）的调控。这些因素通过多种遗传途径如光周期路径、春化路径、年龄路径等，调控开花时间基因的表达，从而诱导植物开花。目前的研究内容：利用模式开花植物拟南芥及小麦，聚焦春化路径及光周期路径，揭示季节转换调控越冬植物在春季开花的分子与表观遗传机制。
代表性科研论文:
1. Zeng X, Gao Z, Gu J, Qin G, Ou Y, Gao Z, Wang P & He Y. (2025) CK2 kinase-PRC2 signalling regulates genome-wide H3K27 trimethylation and transduces prolonged cold exposure into epigenetic cold memory in plants. Nature Plants, 11: 1572-1590.
2. Niu D, Gao Z, Cui B, Zhang Y & He Y. (2024) A molecular mechanism for embryonic resetting of winter memory and restoration of winter annual growth habit in wheat. Nature Plants, 10: 37-52.
3. Huang F, Luo X, Ou Y, Gao Z, Tang Q, Chu Z, Zhu X & He Y. (2023) Control of histone demethylation by nuclear-localized α-ketoglutarate dehydrogenase. Science, 381: eadf8822.
4. Zhang Z, Luo X, Yang, Y & He Y. (2023) Cold induction of nuclear FRIGIDA condensation in Arabidopsis. Nature, 7969: E27-E32.
5. Gao Z, Li Y, Ou Y, Yin M, Chen T, Zeng X, Li R & He Y. (2023) A pair of readers of bivalent chromatin mediate formation of Polycomb-based "memory of cold" in plants. Molecular Cell, 83: 1109-1124.
6. Li Z, Luo X, Ou Y, Jiao H, Peng L, Fu X, Macho AP, Liu R & He Y. (2021) JASMONATE-ZIM DOMAIN proteins engage Polycomb chromatin modifiers to modulate Jasmonate signaling in Arabidopsis. Molecular Plant, 14: 732-747.
7. Luo X, Ou Y, Li R & He Y. (2020) Maternal transmission of the epigenetic 'memory of winter cold' in Arabidopsis. Nature Plants, 6: 1211-1218.
8. Tao Z, Hu H, Luo X, Jia B, Du J* & He Y.* (2019) Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis. Nature Plants, 5: 424-435.
9. Li Z, Fu X, Wang Y, Liu R & He Y. (2018) Polycomb-mediated gene silencing by the BAH-EMF1 complex in plants. Nature Genetics, 50: 1254-1261.
10. Li Z, Jiang D & He Y. (2018) FRIGIDA establishes a local chromosomal environment for FLOWERING LOCUS C mRNA production. Nature Plants, 4: 836-846.
11. Z. Tao, L. Shen, X. Gu, Y. Wang, H. Yu & He Y. (2017) Embryonic epigenetic reprogramming by a pioneer transcription factor in plants. Nature, 551: 124-128.
12. Yuan W, Luo X, Li Z, Yang W, Wang Y, Liu R, Du J & He Y. (2016) A cis cold memory element and a trans epigenome reader mediate Polycomb silencing of FLC by vernalization in Arabidopsis. Nature Genetics, 48: 1527-1534.
