白凡
北京大学生物医学前沿创新中心研究员/教授
北大-清华生命科学联合中心PI
电子邮件：fbai(at)pku(dot)edu(dot)cn
实验室主页：https://biopic.pku.edu.cn/zxpi/107bdswyxqycxzxgb510943.htm
研究领域：
近年来研究重点关注：1）人体正常组织中存在的体细胞突变与肿瘤发生；2）循环肿瘤细胞与癌症多器官转移；3）单细胞精度解析儿童免疫疾病致病机制；4）抗生素杀菌原理和细菌耐药的分子机制。
研究兴趣：
创新和发展单分子荧光成像、单细胞测序、生物信息分析等多学科交叉融合方法，研究临床复杂疾病致病机制，探索新的治疗方法。
代表性科研论文：
1. Gao Y#, Peng Y#, Cheng J#, Zhang X#, Zhong J, Lu C, ......, Liu X, Xiao F, Wang X, Bai F*, Zhang N*, Meningeal blood vessel blockage enhances anti-glioblastoma immunity, Cell 189 (2026), 1305-1322.
2. Xing X#, Zhong J#, Biermann J#, Duan H#, Zhang X#, Shi Y#, ……, Mou Y*, Izar B*, Zhang N*, Bai F*, Pan-cancer human brain metastases atlas at single-cell resolution, Cancer Cell 43 (2025), 1242-1260
3. Li F#, Xing X#, Jin Q#, ……, Yu C*, Chen L*, Bai F*, Gao D*, Sex differences orchestrated by androgens at single-cell resolution, Nature 629 (2024), 193-200
4. Chen L#, Zhang C#, Xue R#, ……, Wu L*, Rozen SG*, Bai F*, Wang H*, Deep whole genome analysis of 494 hepatocellular carcinomas, Nature 624 (2024), 586-593
5. Li R#, Di L#, Li J#, ……, Lin D*, Huang Y*, Wang J*, Bai F*, Wu C*, A body map of somatic mutagenesis in morphologically normal human tissues, Nature 597 (2021), 398-403
6. Li R#, Du Y#, Chen Z#, ……, Xu T*, Bai F*, Macroscopic somatic clonal expansion in morphologically normal human urothelium, Science 370 (2020), 82-89
7. Huang B#, Chen Z#, Geng L#, ......, Gong S*, Bai F*, Yang M*, Zhang Y*, Mucosal profiling of pediatric-onset colitis and IBD reveals common pathogenics and therapeutic pathways, Cell 179 (2019), 1160-1176
8. Pu Y#, Li Y#, Jin X#, ……, Lo CJ, Bai F*, ATP-dependent dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic tolerance, Molecular Cell 73 (2019), 1-14
9. Pu Y#, Zhao Z#, Li Y#, ……, Xie XS*, Bai F*, Enhanced efflux activity facilitates drug tolerance in dormant bacterial cells, Molecular Cell 62 (2016), 284-294
10. Bai F#, Branch R#, Nicolau D#,……, Berry R*, Conformational spread as a mechanism for cooperativity in the bacterial flagellar switch, Science 327 (2010), 685-689
