赵帅

邮箱：shuai@tsinghua.edu.cn

学科方向：肿瘤表观遗传学

研究方向：课题组关注于基因组非编码元件，包括以内源性逆转录病毒（ERV）为代表的反转座子元件的分子调控机理及其对于肿瘤免疫的影响。主要方向包括新型ERV调控元件的发现、ERV元件调控蛋白在癌症的功能、肿瘤中转座元件的空间生物学解析等。

代表性科研论文

(*Co-first author; ^#Co-corresponding author)

1. Zhao S*, Lu J*, Pan B, Fan H, Byrum S, Xu C, Kim A, Guo Y, Kanchi K, Gong W, Sun T, Storey A, Burkholder N, Mackintosh S, Kuhlers P, Edmondson R, Strahl B, Diao Y, Tackett A, Raab J, Cai L, Song J^#, Wang G^# (2023) TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons. Nature 623: 633–642

2. Li Z*, Zhao S*, Nelakanti R*, Lin K*, Wu T*, Alderman III M, Guo C, Wang P, Zhang M, Min W, Jiang Z, Wang Y, Li H^#, Xiao A^# (2020) N6-methyladenine in DNA antagonizes SATB1 in early development. Nature 583: 625-630

3. Zheng Q*, Weekley B*, Vinson D*, Zhao S*, Bastle R*, Thompson R, Stransky S, Ramakrishnan A, Cunningham A, Dutta S, Chan J, Salvo GD, Chen M, Zhang N, Wu J, Fulton S, Kong L, Wang H, Zhang B, Vostal L, Upad A, Dierdorff L, Shen L, Molina H, Sidoli S, Muir T, Li H^#, David Y^#, Maze I^# (2025) Histone monoaminylation dynamics are regulated by a single enzyme and promote neural rhythmicity. Nature 637: 974-982

4. Zhao S, Allis CD, Wang G (2021) The language of chromatin modification in human cancers. Nat. Rev. Cancer 21: 413-430 (Cover Story)

5. Zhao S*, Chuh K*, Zhang B*, Xu N, Xue Y, Liu X, Farrelly F, Thompson R, Roeder R, Maze I^#, Muir T^#, Li H^# (2021) Histone H3Q5 serotonylation stabilizes H3K4me3 and potentiates its readout by TAF3. PNAS 118 (6) e2016742118

6. Zhao S*, Cheng L*, Gao Y*, Zhang B*, Zheng X, Wang L, Li P^#, Sun Q^#, and Li H^# (2019) Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation. Cell Research 29 (1): 54-66

7. Zhao S*, Zhang B*, Yang M, Zhu J, and Li H (2018) Systematic profiling of histone readers in Arabidopsis thaliana. Cell Reports 22: 1090-1102

8. Zhao S*, Yang M*, Zhou W, Zhang B, Cheng Z, Huang J. Zhang M, Wang Z, Wang R, Chen Z, Zhu J^#, and Li H^# (2017) Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology. PNAS 114: E7245-E7254

9. Zhao S, Yue Y, Li Y, Li H (2019) Identification and characterization of “readers” for novel histone modifications. Curr Opin Chem Biol 51: 57-65

10. Zhao S*, Zhang X*, and Li H (2018) Beyond histone acetylation – writing and erasing histone acylations. Curr Opin Struc Biol 53:169–177