李栋
邮箱：li-dong@tsinghua.edu.cn
学科方向：
主要从事光学显微成像技术开发及其生物医学应用研究
研究方向:
李栋课题组致力于光学显微成像技术的开发与生命科学应用研究，特别是开发适于活体、高速、长时程、低损伤的超分辨荧光显微镜成像技术。首创了条纹激活非线性结构光显微镜、掠入射结构光超分辨显微镜，以及合理化深度学习超分辨成像等技术方法。主要研究方向包括：多模态、高速、多色、长时程超分辨显微镜系统研制，深度学习超分辨显微成像算法开发及新型光学成像技术应用于生命科学研究。
代表性科研论文:
1.Qiao C, Liu S, Wang Y, Xu W, Geng X, Jiang T, Zhang J, Meng Q, Qiao H, Li D*, Dai QH*. A neural network for long-term super-resolution imaging of live cells with reliable confidence quantification. Nat Biotechnol. 2025 Jan 29.
2.Qiao C, Chen H, Wang R, Jiang T, Wang Y, Li D*. Deep learning-based optical aberration estimation enables offline digital adaptive optics and super-resolution imaging. Photonics Research, 2024 Dec (3), 474-484
3.Qiao C, Li D, Liu Y, Zhang S, Liu K, Liu C, Guo Y, Jiang T, Fang C, Li N, Zeng Y, He K, Zhu X, Lippincott-Schwartz J*, Dai Q*, Li D*. Rationalized deep learning super-resolution microscopy for sustained live imaging of rapid subcellular processes. Nat Biotechnol. 2023 Mar;41(3):367-377.
4.Qiao C#, Li D#, Guo Y#, Liu C#, Jiang T, Dai Q*, Li D*. Evaluation and development of deep neural networks for image super-resolution in optical microscopy. Nat Methods. 2021 Feb;18(2):194-202.
5.Wang X#*, Liu C#, Zhang S#, Yan H, Zhang L, Jiang A, Liu Y, Feng Y, Li D, Guo Y, Hu X, Lin Y, Bu P, Li D*. N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles. Dev Cell. 2021 Feb 15; 56(5):702-715.
6.Gong B#, Guo Y#, Ding S, Liu X, Meng A, Li D*, Jia S*, A Golgi-derived vesicle potentiates PtdIns4P to PtdIns3P conversion for endosome fission. Nat Cell Biol. 2021 Jul; 23(7):782-795.
7.Xu G#, Liu C#, Zhou S#, Li Q, Feng Y, Sun P, Feng H, Gao Y, Zhu J, Luo X, Zhan Q, Liu S, Zhu S, Deng H*, Li D*, Gao P*. Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion. Mol Cell. 2021 Jul 1;81(13):2823-2837.
8.Qin J, Guo Y, Xue B, Shi P, Chen Y, Su Q, Hao H, Zhao S, Wu C, Yu L, Li D*, Sun Y*. ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation. Nat Commun. 2020 Sep 8;11(1):4471.
9.Li D#, Zhao Y#, Li D, Zhao H, Huang J, Miao G, Feng D, Liu P, Li D*, Zhang H*. The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation. Cell Rep. 2019 Apr 9;27(2):343-358.
10.Guo Y#, Li D#, Zhang S, Yang Y, Liu J, Wang X, Liu C, Milkie D, Moore R, Tulu U, Kiehart D, Hu J, Lippincott-Schwartz J*, Betzig E*, Li D*.Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales. Cell. 2018 Nov 15;175(5):1430-1442.
11.Li D, Shao L, Chen BC, Zhang X, Zhang M, Moses B, Milkie DE, Beach JR, Hammer JA, Pasham M, Kirchhausen T, Baird MA, Davidson MW, Xu P, Betzig E*. Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics. Science. 2015 Aug 28;349(6251): aab3500.
