王继纵

邮箱: wangjizong@tsinghua.edu.cn

学科方向：植物生物学、结构生物学

研究方向：

光是驱动植物光合作用的能量来源，更是调控其生命周期的核心环境信号。本实验室聚焦植物光感知、信号转导与能量利用的前沿领域，综合运用生物化学、结构生物学及遗传学等多学科手段，致力于以下研究：

1.植物红光/远红光信号转导；

2.光合色素的生物合成。

代表性科研论文：

1.Chi C^#, Wang ZD^#, Wang RH, Wang JZ*. (2025). Production of plant phytochromes by combining insect cells and bacterial expression systems. Methods Mol. Biol. 2970:69-80.

2.Wang ZD^#, Wang WF^#, Zhao DD^#, Song YP^#, Lin XL^#, Shen M, Chi C, Xu B, Zhao J, Deng XW*, Wang JZ*. (2024). Light-induced remodeling of phytochrome B enables signal transduction by phytochrome-interacting factor. Cell 187:6235-6250.

3.Zhang YX^#, Lin XL^#, Ma CY^#, Zhao J^#, Shang XJ, Wang ZD, Xu B, Gao N, Deng XW*, Wang JZ*. (2023). Structural insights into plant phytochromes A as a highly sensitized photoreceptor. Cell Res. 33:806-809.

4.Wang JZ*, Song W*, Chai JJ*. (2022). Structure, biochemical function, and signaling mechanism of plant NLRs. Mol. Plant 16:75-95.

5.Wang JZ^#, Hu MJ^#, Wang J^#, Qi JF, Han ZF, Wang GX, Qi YJ, Wang HW*, Zhou JM*, Chai JJ*. (2019). Reconstitution and structure of a plant NLR resistosome conferring immunity. Science 364:eaav5870.

6.Wang JZ^#, Wang J^#, Hu MJ^#, Wu S, Qi JF, Wang GX, Han ZF, Qi YJ, Gao N, Wang HW*, Zhou JM*, Chai JJ*. (2019). Ligand-triggered allosteric ADP release primes a plant NLR complex. Science 364:eaav5868.

7.Wang JZ^#, Li HJ^#, Han ZF, Zhang HQ, Wang T, Lin GZ, Chang JB, Yang WC*, Chai JJ*. (2015). Allosteric receptor activation by the plant peptide hormone phytosulfokine. Nature 525:265-268.

#: Co-first author;  *: Corresponding author