姜长涛

电子邮件：jiangchangtao@bjmu.edu.cn

实验室主页：https://sbms.bjmu.edu.cn/jsdw/bssds/Changtao_Jiang.html

研究方向：

甾体是一大类广泛存在于生物体的重要活性分子，包括胆固醇、胆汁酸、性激素、维生素D、肾上腺激素等，在维持细胞膜流动性、调节代谢稳态及介导信号转导等生命活动中发挥着不可或缺的作用。肠道微生物对膳食及宿主来源甾体具有广泛的代谢作用，形成了高度多样性与动态转化的菌源甾体代谢网络，这一网络是机体甾体稳态维持的核心基石，深刻影响着宿主代谢健康，但目前我们对于其代谢和功能仍知之甚少。

我们课题组致力于运用生理学、化学生物学、微生物学及AI等多学科交叉技术，重点关注肠道微生物甾体代谢（代谢物及其酶）的生化规律与调控网络。重点开发菌源甾体代谢酶的功能挖掘体系，鉴定新型菌源甾体代谢物及其受体，阐明其在宿主代谢稳态维持中的分子机制，为相关疾病干预提供新靶点与新策略。

具体方向如下：

1、探究甾体代谢物及其酶的动物进化与微生物协同机制，阐明其跨界代谢调控的生命逻辑

2、解析菌源甾体代谢物调控机体代谢的受体与分子机制，开发靶向性疾病干预新策略

3、构建基于AI的菌源甾体代谢酶挖掘技术，发现新型活性甾体代谢物

代表性论文

1.Ding, Y.^#, Luo, X.^#, Guo, J.^#, Xing, B.^#, Lin, H.^#, Ma, H., Wang, Y., Li, M., Ye, C., Yan, S., Lin, K., Zhang, J., Zhuo, Y., Nie, Q., Yang, D., Zhang, Z., Pang, Y., Wang, K.^*, Ma, M.^*, Lai, L.^*,Jiang, C. T.^*(2025). Identification of gut microbial bile acid metabolic enzymes via an AI-assisted pipeline.Cell.188, 6012-6027.

2.Lin, J.^#, Nie, Q.^#, Cheng, J.^#, Zhong, Y. N.^#, Zhang, T.^#, Zhang, X.^#, Ge, X.^#, Ding, Y.^#, Niu, C., Gao, Y., Wang, K., Gao, M., Wang, X., Chen, W., Yun, C., Ye, C., Xu, J., Shaoyong, W., Zhang, L., Shang, P., Luo, X., Zhang, Z., Zheng, X., Sha, X., Zhang, J., Nie, S., Zhang, X., Ren, F., Liu, H., Dong, E., Yu, X.^*, Ji, L.^*, Pang, Y.^*, Sun, J.^*,Jiang, C. T.^*(2025). A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE.Cell.188, 4530-4548.

3.Zhou, S.^#, Li, M.^#, Wang, P.^#, Guo, C., Zhang, J., Luo, X., Fan, Y. C., Chen, E. Q., Qi, X., Chen, J., Ye, L., Yuan, H. Y., Yin, W. B., Wang, K.^*, Zheng, M. H.^*, Pang, Y.^*, Qiao, J.^*,Jiang, C. T.^*(2025). A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite-CerS6-ceramide axis.Science.388, eadp5540.

4.Nie, Q.^#, Luo, X.^#, Wang, K.^#, Ding, Y.^#, Jia, S.^#, Zhao, Q., Li, M., Zhang, J., Zhuo, Y., Lin, J., Guo, C., Zhang, Z., Liu, H., Zeng, G., You, J., Sun, L., Lu, H., Ma, M., Jia, Y.^*, Zheng, M.^*, Pang, Y.^*, Qiao, J.^*,Jiang, C. T.^*(2024). Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway.Cell.187, 2717-2734.

5.Wang, K.^#, Zhang, Z.^#, Hang, J.^#, Liu, J.^#, Guo, F.^#, Ding, Y., Li, M., Nie, Q., Lin, J., Zhuo, Y., Sun, L., Luo, X., Zhong, Q., Ye, C., Yun, C., Zhang, Y., Wang, J., Bao, R., Pang, Y., Wang, G.^*, Gonzalez, F.^*, Lei, X.^*, Qiao, J.^*,Jiang, C. T.^*(2023). Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target.Science.381, eadd5787.

6.Chen, B.^#, Sun, L.^#, Zeng, G.^#, Shen, Z.^#, Wang, K.^#, Yin, L.^#, Xu, F., Wang, P., Ding, Y., Nie, Q., Wu, Q., Zhang, Z., Xia, J., Lin, J., Luo, Y., Cai, J., Krausz, K. W., Zheng, R., Xue, Y., Zheng, M.^*, Li, Y.^*, Yu, C.^*, Gonzalez, F.^*,Jiang, C. T.^*(2022). Gut bacteria alleviate smoking-related NASH by degrading gut nicotine.Nature.610, 562-568.

7.Lin, H.^#, Ma, C.^#, Cai, K.^#, Guo, L.^#, Wang, X.^#, Lv, L.^#, Zhang, C.^#, Lin, J.^#, Zhang, D., Ye, C., Wang, T., Huang, S., Han, J., Zhang, Z., Gao, J., Zhang, M., Pu, Z., Li, F., Guo, Y., Zhou, X., Qin, C., Yi, F., Yu, X.^*, Kong, W.^*,Jiang, C. T.^*and Sun, J.^*(2025). Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis.Science.388, eado4188.

8.Zhang, S.^#, Lin, H.^#, Wang, J.^#, Rui, J.^#, Wang, T.^#, Cai, Z.^#, Huang, S.^#, Gao, Y., Ma, T., Fan, R., Dai, R., Li, Z., Jia, Y., Chen, Q., He, H., Tan, J., Zhu, S., Gu, R., Dong, Z., Li, M., Xie, E., Fu, Y., Zheng, J.^*,Jiang, C. T.^*, Sun, J.^*and Kong, W.^*(2025). Sensing Ceramides by CYSLTR2 and P2RY6 to Aggravate Atherosclerosis.Nature.641, 476-485.

9.Wu,Q.^#, Liang, X.^#, Wang, K.^#, Lin, J., Wang, X., Wang, P., Zhang, Y., Nie, Q., Liu, H., Zhang, Z., Liu, J., Pang, Y. L.,Jiang, C. T.*. (2021) Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis.Cell Metabolism.33, 1988-2003.

10.Sun, L.^#, Xie, C.^#, Wang, G.^#, Wu, Y.^#, Wu, Q., Wang, X., Liu, J., Deng, Y., Xia, J., Chen, B., Zhang, S., Yun, C., Lian, G., Zhang, X., Zhang, H., Bisson, W. H., Shi, J., Gao, X., Ge, P., Liu, C., Krausz, K. W., Nichols, R. G., Cai, J., Rimal, B., Patterson, A. D., Wang, X., Gonzalez, F. J.,Jiang, C. T.*.(2018) Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.Nature Medicine.24, 1919-1929.