方晓峰

电子邮件：xffang@tsinghua.edu.cn

通讯地址：清华大学生物技术馆4-214室

实验室主页：http://fanglab.org.cn/

研究方向：

生物大分子（如RNA与蛋白质）能够通过液-液相分离在细胞中形成分子凝聚体，广泛地参与不同生物学过程，这使得相分离成为目前生物学领域最前沿的研究之一。相分离这一机制不仅更新了我们对许多生物学问题的理解，也为我们研究生物学问题提供了新的思路。实验室利用生物学、物理学、化学和分子模拟等多学科手段研究相分离在植物生长发育以及感受、应答和记忆环境胁迫过程中的作用及机制。

代表性论文（#共同第一作者，*通讯或共同通讯作者）：

1.Miao Y, Wang Y, Grate E.V.L, Fang X*. (2026) A multidimensional view of biomolecular condensates in plant biology. Annual Review of Plant Biology. In press

2.Fang X*, May AI, Sporbeck K, Hauer L, Knorr RL*. (2025) Wet scissors: How biomolecular condensates cut cellular membranes. Current Opinion in Plant Biology. 86:102740.

3.Geng P^#, Li C^#, Quan X^#, Peng J^#, Yao Z, Wang Y, Yang M, Xiong Y, Liu H, Qi Y, Yang P, Huang K*, Fang X*. (2025) A thermosensor FUST1 primes heat-induced stress granule formation via biomolecular condensation in Arabidopsis. Cell Research. 35(7):483-496.

4.Wu J, Wang Y, Chen H, Xu T, Yang W, Fang X*. (2025) Solid-like condensation of MORF8 inhibits RNA editing under heat stress in Arabidopsis. Nature Communications. 16(1):2789.

5.Peng J^#, Yu Y^#, Fang X*. (2025) Stress sensing and response through biomolecular condensates in plants. Plant Communications. 6(2):101225.

6.Wang Y^#, Li S^#, Mokbel M^#, May AI, Liang Z, Zeng Y, Wang W, Zhang H, Yu F, Sporbeck K, Jiang L, Aland S, Agudo-Canalejo J, Knorr RL*, Fang X*. (2024) Biomolecular condensates mediate bending and scission of endosome membranes. Nature. 634(8036):1204-1210.

7.Miao Y*, Chodasiewicz M*, Fang X*. (2024) Navigating biomolecular condensates in plants from patterns to functions. Molecular Plant. 17(9):1329-1332.

8.Fang X*, Li P*. (2024) SnapShot: Condensates in plant biology. Cell. 187(11):2894-2894.

9.Wang Y, He S*, Fang X*. (2023) Emerging roles of phase separation in plant transcription and chromatin organization. Current Opinion in Plant Biology. 75:102387

10.Zhang H^#, Peng F^#, He C^#, Liu Y^#, Deng H*, Fang X*. (2023) Large-scale identification of potential phase separation proteins from plants using a cell-free system. Molecular Plant. 16(2):310-313.

11.Wang B^#, Zhang H^#, Huai J^#, Peng F, Wu J, Lin R*, Fang X*. (2022) Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis. Nature Chemical Biology. 18(12):1361-1369.

完整论文列表请见：

https://www.ncbi.nlm.nih.gov/myncbi/xiaofeng.fang.1/bibliography/public/