段小洁

电子邮件: xjduan@pku.edu.cn

研究领域：全脑大尺度神经环路动力学与脑功能机制

实验室地址：北京市海淀区颐和园路5号，北京大学，新奥工学大楼，100871

研究方向:

脑内广泛分布且高度复杂的神经活动是各类行为与认知功能的核心基础，解析神经活动调控行为的内在机制，是系统神经科学的核心研究目标。传统神经电生理技术存在采样区域局限、神经元记录数量偏少等短板，难以真实还原行为过程中全脑分布式神经网络的协同动态规律，且长久以来在同步记录神经元规模上进展缓慢，极大制约了相关领域研究推进。

本团队聚焦研发大规模、高分辨在体神经信号采集与解析新技术。前期工作已研制出 1024 通道高密度柔性神经探针，可在啮齿类及非人灵长类动物大脑中实现全纵深范围的单神经元大规模电生理记录，助力解析全脑多脑区大范围神经活动的协同调控规律。同时研发超薄可形变柔性电极阵列，实现大面积电极微创植入，支撑大范围皮层脑电信号测绘与脑电振荡时空动态机制探究；还研发出磁共振成像兼容的深部脑刺激电极，借助该器件在动物模型中证实外侧缰核靶向刺激具备起效迅速、应答率高的抗抑郁效应。未来工作将依托这套大规模、高分辨电生理平台，开展决策行为神经动力学及神经退行性疾病环路异常机制研究，最终为新型神经调控治疗策略的研发提供重要理论依据与实验支撑。

代表性科研论文:

1.Liu, Y., Jia, H., Sun, H., Jia, S., Yang, Z., Li, A., Jiang, A., Naya, Y., Yang, C., Xue, S., Li, X., Chen, B., Zhu, J., Zhou, C., Li, M. and Duan, X.*, A high-density 1024-channel probe for brain-wide neural activity mapping in primates, Nat. Neurosci. 2024, 27, 1620-1631

2.Wei, S., Jiang, A., Sun, H., Zhu, J., Jia, S., Liu, X., Xu, Z., Zhang, J., Shang, Y, Fu, X., Li, G., Wang, P., Xia, Z., Jiang, T., Cao, A. and Duan, X.*, Shape-changing electrode array for minimally invasive large-scale intracranial brain activity mapping. Nat. Commun. 2024: 15: 715

3.Li, G., Bo, B., Wang, P., Qian, P., Li, M., Li, Y., Tong, C., Zhang, K., Zhang, B., Jiang, T., Liang, Z.* and Duan, X.*, Instantaneous antidepressant effect of lateral habenula deep brain stimulation in rats studied with functional MRI. eLife 2023, 12: e84693

4.Yu, Y., Qiu, Y., Li, G., Zhang, K., Bo, B., Pei, M., Ye, J., Thompson, G.J., Cang, J., Fang, F., Feng, Y., Duan, X.*, Tong C.* and Liang, Z.*, Sleep fMRI with simultaneous electrophysiology at 9.4 T in male mice. Nat. Commun. 2023, 14:1651

5.Liu, X., Xu, Z., Fu, X., Liu, Y., Jia, H., Yang, Z., Zhang, J., Wei, S, and Duan, X.*, Stable, long-term single-neuronal recording from the rat spinal cord with flexible carbon nanotube fiber electrodes. 2022, J. Neural Eng. 19: 056024

6.Fu, X., Li, G., Niu, Y., Xu, J., Wang, P., Zhou, Z., Ye, Z., Liu, X., Xu, Z., Yang, Z., Zhang, Y., Lei, T., Zhang, B., Li, Q., Cao, A., Jiang, T. and Duan, X.*, Carbon-based fiber materials as implantable depth neural electrodes. Front Neurosci. 2021, 15, 771980

7.Meng, X., Cheng, Y., Wang, P., Chen, K., Chen, Z., Liu, X., Fu, X., Wang, K., Liu, K., Liu, Z. and Duan, X.*, Enhanced hemocompatibility of a direct chemical vapor deposition-derived graphene film. 2021, ACS Appl Mater Interfaces. 13, 4835-4843

8.Zhao, S., Li, G., Tong, C., Chen, W., Wang, P., Dai, J., Fu, X., Xu, Z, Liu, X., Lu, L., Liang, Z.* and Duan, X.*, Full activation pattern mapping by simultaneous deep brain stimulation and fMRI with graphene fiber electrodes, 2020, Nat. Commun. 11: 1788