参考文献
1.Goodrich LV, Strutt D. Principles of planar polarity in animal development. Development 2011;138:1877-92.
2.Etienne-Manneville S, Hall A. Rho GTPases in cell biology. Nature 2002;420:629-35.
3.Bilder D, Li M, Perrimon N. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 2000;289:113-6.
4.Macara IG. Parsing the polarity code. Nat Rev Mol Cell Biol 2004;5:220-31.
5.Kemphues KJ, Priess JR, Morton DG, et al. Identification of genes required for cytoplasmic localization in early C. elegans embryos. Cell 1988;52:311-20.
6.Cuenca AA, Schetter A, Aceto D, et al. Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases. Development 2003;130:1255–65.
7.Tostevin F, Howard M. Modeling the establishment of PAR protein polarity in the one-cell C. elegans embryo. Biophys J 2008;95:4512-22.
8.Chau AH, Walter JM, Gerardin J, et al. Designing synthetic regulatory networks capable of self-organizing cell polarization. Cell 2012;151:320-32.
9.Kumfer KT, Cook SJ, Squirrell JM, et al. CGEF-1 and CHIN-1 regulate CDC-42 activity during asymmetric division in the Caenorhabditis elegans embryo. Mol Biol Cell 2010;21:266-77.
10.Beatty A, Morton D, Kemphues K. The C. elegans homolog of Drosophila lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo. Development 2010;137:3995-4004.
11.Sailer A, Anneken A, Li Y, et al. Dynamic opposition of clustered proteins stabilizes cortical polarity in the C. elegans zygote. Dev Cell 2015;35:131-42.
12.Seirin-Lee S, Gaffney EA, Dawes AT. CDC-42 interactions with Par proteins are critical for proper patterning in polarization. Cells 2020;9:2036.
13.Lim YW, We FL, Shankar P, et al. A balance between antagonizing PAR proteins specifies the pattern of asymmetric and symmetric divisions in C. elegans embryogenesis. Cell Rep 2021;36:109326.
14.Lang CF, Munro E. The PAR proteins: From molecular circuits to dynamic self-stabilizing cell polarity. Development 2017;144:3405-16.
15.Rodriguez J, Peglion F, Martin J, et al. aPKC cycles between functionally distinct PAR protein assemblies to drive cell polarity. Dev Cell 2017; 42:400-15.e9.
16.Arata Y, Lee JY, Boldstein B, et al. Extracellular control of PAR protein localization during asymmetric cell division in the C. elegans embryo. Development 2010;137:3337-45.
17.Seirin-Lee S. Positioning of polarity formation by extracellular signaling during asymmetric cell division. J Theor Biol 2016;400:52-64.
18.Watson JL, Krüger LK, Ben-Sasson AJ, et al. Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells. Cell 2023;186:4710-27.
19.Hubatsch L, Peglion F, Reich JD, et al. A cell-size threshold limits cell polarity and asymmetric division potential. Nat Phys 2019;15:1075-85.
20.Cao J, Guan G, Ho VWS, et al. Establishment of a morphological atlas of the Caenorhabditis elegans embryo using deep-learning-based 4D segmentation. Nat Commun 2020;11:6254.
21.Guan G, Li Z, Ma Y, et al. Cell lineage-resolved embryonic morphological map reveals signaling associated with cell fate and size asymmetry. Nat Commun 2025;16:3700.
22.Guan G, Wong M-K, Zhao Z, et al. Volume segregation programming in a nematode’s early embryogenesis. Phys Rev E 2021;104:054409.
23.Tian B, Guan G, Tang L-H, et al. Why and how the nematode's early embryogenesis can be precise and robust: A mechanical perspective. Phys Biol 2020;17:026001.
24.Kuang X, Guan G, Wong MK, et al. Computable early Caenorhabditis elegans embryo with a phase field model. PLoS Comput Biol 2022;18:e1009755.
25.Guan G, Luo C, Tang L-H, et al. Modulating cell proliferation by asymmetric division: A conserved pattern in the early embryogenesis of nematode species. MicroPubl Biol 2024;10.17912/micropub.biology.001006.