George M. Shaw, M.D. Ph.D.
Professor of Medicine and Microbiology, University of Pennsylvania
Education
B.A. Dartmouth College, 1975.
Ph.D. (Pharmacology) The Ohio State University, 1979.
M.D. The Ohio State University, 1980.
Professional Experience
Internship in Medicine, Department of Medicine, University of Michigan Medical Center, Ann Arbor, MI, 1980-1981.
Resident in Medicine, Department of Medicine, University of Michigan Medical Center, Ann Arbor, MI, 1981-1983.
Postdoctoral Fellowship, Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 1983-1985.
Topic: Elucidation of Hepatitis C Virus Transmission, Diversification and Selection by Single Genome Sequencing
I have interests in HIV-1, SIV and hepatitis C virus (HCV) transmission, pathogenesis, treatment and prevention. My laboratory has developed novel molecular insights into HIV/SIV/HCV replication dynamics and transmission based on quantitative estimates of plasma virus RNA load, kinetics and diversity (Wei et al., Nature 1995; Wei et al., Nature 2003; Keele et al., PNAS 2008; Salazar et al., J Exp Med 2009; Li et al., PLoS Pathogens 2012). Importantly, we have shown that we can identify transmitted/founder HIV-1, SIV and HCV genomes that are responsible for productive clinical infection in recently infected subjects. This represents a transformative experimental approach for studying virus transmission and evolution in the face of innate and adaptive immune responses and following the initiation of potent antiviral drug therapy.
Venue: Room143, New Biology Building, THU
Time: Nov.9 (Friday), 2012; 16:00
Host: Prof. Linqi Zhang
