Building Integrative Frameworks to Study Autism Spectrum Disorders

Michael Snyder PhD

Professor and Chair of Genetics

Director, Stanford Center for Genomics and Personalized Medicine

Co-Principal Investigator at Center for Personal Dynamic Regulomes

Biography：

Dr. Michael Snyder is the Stanford Ascherman Professor and Chair of Genetics and the Director of the Center of Genomics and Personalized Medicine. Dr. Snyder is a leader in the field of functional genomics and proteomics, and one of the major participants of the ENCODE project. His laboratory study was the first to perform a large-scale functional genomics project in any organism, and has developed many technologies in genomics and proteomics, including proteome chips, high resolution tiling arrays, ChIP-chip (now replaced by ChIP-seq), paired end sequencing for mapping of structural variation, and RNA-Seq, to name a few. He has also combined different state-of–the-art “omics” technologies to perform the first longitudinal detailed integrative personal omics profile (iPOP) of person and used this to assess disease risk and monitor disease states for personalized medicine. He is a cofounder of several biotechnology companies and presently serves on the board of a number of companies.

Abstract：

Mutational heterogeneity is common among many complex human diseases, where even for the same disease, different patients tend to carry different sets of mutations. Using autism spectrum disorders as an example, all professionals in this field know the truth of the saying “If you’ve seen one individual with autism, you’ve seen one individual with autism”. Given such extreme locus heterogeneity, it is often challenging to apply the traditional statistical techniques to identify the genetic architecture underlying complex human diseases. In this talk I will discuss our systems frameworks to unveil the hidden genetic architecture in complex human diseases. Focusing on autism spectrum disorders, we integrated multi-omics profiling approaches with molecular network analysis, and identified modules of highly interacting proteins that are strongly involved in autism.

Time: Aug. 8th, 2016, 10:00

Venue: New Biology Building, Room 143

Host: Drs. Michael Q. Zhang, Qiangfeng Cliff Zhang

举办单位：生命科学联合中心