Three Types of Cell Competition and Their Roles in Development, Cancer and Ageing

Eduardo Moreno

Champalimaud Foundation,

Portugal

Abstract:

During my talk I will argue that in multicellular animals there are three different and non-exclusive modes of competition: trophic competition for extracellular survival factors and resources (Moreno et al., Nature, 2002), competition through fitness fingerprints (Rhiner et al., Dev. Cell, 2010; Merino et al., Cell, 2015; Levayer et al., Nature, 2015), and competition through mechanical stress (Levayer et al. Curr. Biol., 2016). I will discuss the differences and similarities between the three types and their role in ageing, development and cancer.

Latest publications:

· Levayer R, Dupont C, Moreno E. (2016) Tissue Crowding Induces Caspase-Dependent Competition for Space. Curr. Biol.

· Levayer R, Hauert B, Moreno E (2015) Cell mixing induced by myc is required for competitive tissue invasion and destruction. Nature

· Casas-Tinto, S., Lolo, F. and Moreno E (2015) Active JNK-dependent secretion of Drosophila Tyrosyl-tRNA synthetase by loser cells recruits haemocytes during cell competition. Nat. Commun.

· Merino MM, Rhiner C, Lopez-Gay JM, Buechel D, Hauert B, Moreno E (2015) Elimination of unfit cells maintains tissue health and prolongs lifespan. Cell

· Moreno E, Fernandez-Marrero Y, Meye, P, Rhiner C (2015) Brain regeneration in Drosophila involves comparison of neuronal fitness. Curr. Biol.

Time: 16:30--17:30 pm, March 21st, 2017 (Tuesday)

Venue: New Biology Building, Room 143

Host: Jose C. Pastor-Pareja

jose.pastor@biomed.tsinghua.edu.cn