Abstract

C

D4+ T lymphocytes play important regulatory roles in the adaptive immunity. Upon activation, naïve CD4+ helper T (TH) cells differentiate into effector subsets with different cytokine expression profiles and immune regulatory function. Effector TH cells have been classified into TH1 and TH2 lineages: TH1 cells express IFN, and TH2 cells produce IL-4, -5 and -13. More recently, several other subsets of TH cells, including TH17 and Tfh cells have been identified and may play important roles in autoimmune diseases. In the presentation, I will discuss our recent work on the regulation and function of novel CD4+ T cell subsets.