生命科学联合中心

学术报告

题 目: Epigenetic Inheritance and Epigenetic Causes of Brain Tumor.

报告人: ZHIGUO ZHANG, Ph.D

Professor of Biochemistry and Molecular Biology, Mayo Clinic

Director of Epigenomic Development Laboratory, Center of Individualized Medicine, Mayo Clinic

时 间: 2012年4月8日（星期一），下午 13:00-14:00 pm

地 点: 北京大学新生物楼邓佑才报告厅

联系人: 生命科学联合中心，李晴（Tel：6275-2516）

相关下载：Zhiguo ZhangCV，参考文献。

Our first long-term goal is to determine how epigenetically determined chromatin states are inherited during S phase of the cell cycle. Towards this goal, we have been using the budding yeast, mammalian cell culture and mouse as models to address this fundamental, but poorly understood cellular process. Our second long-term goal is to translate our basic science discoveries into diagnostic tools and/or treatments for human diseases. Specifically, we are interested in determining how epigenetic alterations contribute to the development of glioblastoma, the most aggressive brain tumors and in identifying small molecule inhibitors against Rtt109, a lysine a cetyltransferase we discovered, for anti-fungal infection. In this seminar, I will discuss our recent studies on how histone ubiquitylation regulates DNA replication-coupled nucleosome assembly and how a histone H3.3 mutation frequently found in high-grade pediatric glioma reprograms epigenetic landscape , which in turn promotes tumorigenesis .

欢迎感兴趣的老师和同学参加！