Introduction of the speaker:

高绍荣博士1970年出生于山东章丘，1993年毕业于山东农业大学，1999年于中国科学院动物研究所获得博士学位。现为同济大学生命科学与技术学院教授，院长。

高绍荣博士主要利用体细胞核移植与诱导多能干细胞技术从事哺乳动物早期胚胎发育和体细胞重编程分子机制与干细胞研究，在体细胞重编程分子机制和诱导多能干细胞多能性等多项研究中取得一系列重要进展，其中在2009年与中科院动物研究所周琪实验室分别独立报道了iPS小鼠的研究成果，在世界上首次证明了iPS细胞的真正多能性，被美国TIMES评为2009年世界十大医学突破之一。高绍荣博士是国家杰出青年科学基金获得者, 科技部中青年科技创新领军人才，并担任“干细胞研究”国家重大科学研究计划专家组成员。 研究成果曾获国家自然科学二等奖，“周光召基金会杰出青年基础科学奖”和“谈家桢生命科学创新奖”。

Topic: Epigenetic Regulation in Early Embryo

Development and Somatic Cell Reprogramming

Speaker: Shaorong Gao, Ph.D.

Professor and Dean

School of Life Sciences and Technology

Tongji University

Abstract:

Somatic cell nuclear transfer (SCNT) and the induction of pluripotency by defined factors are two most efficient methods used for reprogramming of terminally differentiated somatic cells into pluripotent or even totipotent state. Previously, the full pluripotency of the so-called induced pluripotent stem cells (iPSCs) has been demonstrated for the first time by our lab as viable mice could be generated autonomously from iPS cells through tetraploid blastocyst complementation. However, the molecular mechanism underlying these two reprogramming approaches remains elusive. In this seminar, I will introduce the advances that we achieved recently in understanding the molecular mechanism of both SCNT- and defined transcription factors mediated somatic cell reprogramming.