【北京大学 大学堂】Bioorthogonal chemistry, from basic science to clinical translation
主题：Bioorthogonal chemistry,from basic science to clinical translation
地点：燕京学堂二体地下B101报告厅
主讲人：Carolyn Bertozzi
时间：2025年8月28日，15：:0-16:30
报告摘要
Chemistry designed for living systems, termed “bioorthogonal chemistry”, has enabled new approaches for biological research. We initially developed these reactions for applications to glycobiology, which led to the discovery of new roles for cell-surface glycans in cancer and new types of glycoconjugates including glycoRNA. Bioorthgonal and related click chemistry reactions are now impacting drug development by enabling new approaches to bioconjugate drugs (e.g., antibody-drug conjugates). This presentation will overview the history of the field and recent examples of clinical translation.
报告人简介
Carolyn Bertozzi
斯坦福大学Anne T. and Robert M. Bass讲席教授，霍华德休斯医学研究所研究员，美国国家科学院、艺术与科学院、医学院、发明家科学院院士，2022年诺贝尔化学奖得主。Carolyn Bertozzi教授于1988年从哈佛大学获得化学学士学位，1993获加州大学伯克利分校化学博士学位。在加州大学旧金山分校完成细胞免疫学领域的博士后研究后，于1996年加入加州大学伯克利分校开展独立研究，2015年6月加入斯坦福大学。Carolyn Bertozzi教授的研究横跨化学与生物学领域，关注疾病相关糖生物学并开发全新治疗方法，开创了“生物正交化学”这一研究领域。
Carolyn Bertozzi is the Anne T. and Robert M. Bass Professor of Chemistry and Professor of Chemical & Systems Biology and Radiology (by courtesy) at Stanford University, and an Investigator of the Howard Hughes Medical Institute. She completed her undergraduate degree in Chemistry from Harvard University in 1988 and her Ph.D. in Chemistry from UC Berkeley in 1993. After completing postdoctoral work at UCSF in the field of cellular immunology, she joined the UC Berkeley faculty in 1996. In June 2015, she joined the faculty at Stanford University coincident with the launch of Stanford's Sarafan ChEM-H Institute. Prof. Bertozzi's research interests span the disciplines of chemistry and biology with an emphasis on developing new therapeutic modalities that target disease-related glycobiology. She founded the field of bioorthogonal chemistry, for which she shared the 2022 Nobel Prize in Chemistry. She is an elected member of the Institute of Medicine, National Academy of Sciences, National Academy of Inventors and American Academy of Arts and Sciences.
