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May 16th Seminar-Structure-funcion studies of cytosolic DNA sensors governing the interferon response.



Topic:  Structure-funcion studies of cytosolic DNA sensors governing the interferon response.


Speaker:    Prof. Dinshaw J. Patel

Member and Abby Rockefeller Mauzé Chair in Experimental Therapeutics,

Structural Biology Program,

Memorial Sloan-Kettering Cancer Center,

New York, USA.


The lecture will outline recent results that have emerged from a collaborative program (1) on the metazoan cytoplasmic dsDNA sensor cyclic GMP-AMP synthase (cGAS). These studies address the role of cyclic GMP-AMP (cGAMP) as a metazoan second messenger triggering an interferon response, with the cGAMP linkage isomer c[G(2’,5’)pA(3’,5’)p] generated from GTP and ATP by DNA-activated cGAS. Our structural-functional studies will highlight how a single catalytic pocket can generate c[G(2’,5’)pA(3’,5’)p] through a step-wise cyclization process, thereby identifying and structurally/chemically characterizing a founding member of a new family of metazoan cyclic hetero dinucleotide second messengers. The lecture will also outline structure-function studies of the activation of signaling protein STING (stimulator of interferon genes) by c[G(2’,5’)pA(3’,5’)p], its linkage isomers and drug DMXAA.

Host:       Prof. Yigong Shi

Date:       4:00PM-5:00PM, May 16th (Friday)

Venue:    143, New Biology Building



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