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Yangming Wang

Yangming Wang

Email: yangming.wang(at)pku(dot)edu(dot)cn;

Telephone: +86-10-82545684;

Lab Homepage: http://www.imm.pku.edu.cn/news.php?id=1159


Research Area:

Recent studies revealed that a large fraction of animal genome is transcribed, but only a very small number of these transcripts encode proteins. The functional roles and working mechanisms of the noncoding RNAs remain to be a mystery in biology. We are interested in the biological function of noncoding sequences including untranslated regions of mRNAs (UTRs), small noncoding RNAs, long noncoding RNAs, and their regulators such as RNA binding proteins, in the context of stem cell biology and cancer biology.


Selected Publications:

1. Y. Wang and R. Blelloch, “Cell cycle regulation by microRNAs in embryonic stem cells”,
Cancer Research 2009, 69, 4093-4096.
2. Y. Wang, S. Baskerville, A. Shenoy, J.E. Babiarz, L. Baehner and R. Blelloch, “Embryonic Stem Cell Specific microRNAs Regulate the G1/S Transition and Promote Rapid Proliferation”, Nature Genetics 2008, 40, 1478-1483. (Highlighted in Nature Reports Stem Cells; featured in News and Views in Nature Genetics, 2008, 40, 1391-1392; previewed in Cell Stem Cell, 2009, 4, 9-10)
3. J.E. Babizrz, J.G. Ruby, Y. Wang, D.P. Bartel, and R. Blelloch, “Endogenous shRNAs, siRNAs, and Other Microprocessor-independent, Dicer-dependent Small RNAs in Mouse ES cells”, Genes & Development 2008, 22, 2773-2785.
4. Y. Wang, R. Medvid, C. Melton, R. Jaenisch, and R. Blelloch, “DGCR8 is Essential for microRNA Biogenesis and Silencing of Embryonic Stem Cell Self-Renewal”, Nature Genetics 2007, 39, 380-385.
5. Y. Wang and S. K. Silverman, “Efficient One-Step Synthesis of Biologically Related Lariat RNAs by a Deoxyribozyme”, Angewandte Chemie International Edition 2005, 44, 5863-5866. (Highlighted in Nature Chemical Biology, 2005, 1, 195)
6. Y. Wang and S. K. Silverman, “Deoxyribozymes that Synthesize Branched and Lariat RNA”, Journal of the American Chemical Society 2003, 125, 6880-6881.


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