Lei Liu

 

E-mail：lliu(at)mail(dot)tsinghua(dot)edu(dot)cn

Tel：+86-10-62780027

 
Research Area:
1. Chemical synthesis and modification of proteins. Development of new methods and technologies for synthesis of larger and more complex proteins. Application of chemically synthesized proteins to the study of biochemistry and biophysics.
2. Catalytic synthesis of bioactive small molecules. Development of new transition metal-catalyzed reactions for synthesis of bioactive small molecules. Application of synthetic small molecules to the study of biochemistry and pharmaceutical science.
 

Selected Publications:

1.Yiming Li, Maiyun Yang, Yichao Huang, Xiaoda Song, Lei Liu* and Peng R. Chen*. Genetically encoded alkenyl–pyrrolysine analogues for thiol–ene reaction mediated site-specific protein labeling. Chem. Sci., 2012, 3, 2766–2770

2.Ge-Min Fang.; Jia-Xing Wang.; Lei Liu*. Convergent Chemical Synthesis of Proteins by Ligation of Peptide Hydrazides. Angew. Chem. Int. Ed. 2012, 51, 10347-10350.

3.Yi-Ming Li, Mai-Yun Yang, Yi-Chao Huang, Yi-Tong Li, Peng R. Chen,* and Lei Liu*, Ligation of Expressed Protein -Hydrazides via Genetic Incorporation of an -Hydroxy Acid. ACS Chem. Biol. 2012, 7, 1015−1022

4.Ji-Shen Zheng; Shan Tang; Ye Guo; Hao-Nan Chang; Lei Liu*. Synthesis of Cyclic Peptides and Cyclic Proteins via Ligation of Peptide Hydrazides. ChemBioChem 2012, 13, 542–546.

5.Chu-Ting Yang, Zhen-Qi Zhang, Jun Liang, Jing-Hui Liu, Xiao-Yu Lu, Huan-Huan Chen, Lei Liu*, Copper-Catalyzed Cross-Coupling of Nonactivated Secondary Alkyl Halides and Tosylates with Secondary Alkyl Grignard Reagents. J. Am. Chem. Soc. 2012, 134, 11124−11127

6.Fang GM, Li YM, Shen F, Huang YC, Li JB, Lin Y, Cui HK, Liu L.* Protein chemical synthesis via ligation of peptide hydrazides. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50, 2011, in press.

7.Zheng JS, Chang HN, Wang FL, Liu L.* Fmoc synthesis of peptide thioesters without post-chain assembly manipulation. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 133, 2011, in press.

8.Gong TJ, Xiao B, Liu ZJ, Wan J, Xu J, Luo DF, Fu Y, Liu, L.* Rhodium-catalyzed selective C-H activation/olefination of phenol carbamates. ORGANIC LETTERS 13, 3235-3237, 2011.

9.Xiao B, Gong TJ, Liu ZJ, Liu JH, Luo DF, Xu J, Liu L.* Synthesis of dibenzofurans via palladium-catalyzed phenol-directed C-H activation/C-O cyclization. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 133, 9250-9253, 2011.

10.Yang CT, Zhang ZQ, Liu YC, Liu L.* Copper-catalyzed cross-coupling reaction of organoboron compounds with primary alkyl halides and pseudohalides. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50, 3904-3907, 2011.

11.Shang R, Ji DS, Chu L, Fu Y, Liu L.* Synthesis of a-aryl nitriles through palladium-catalyzed decarboxylative coupling of cyanoacetate salts with aryl halides and triflates. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50, 4470-4474, 2011.

12.Shen F, Zhang ZP, Li JB, Lin Y, Liu L.* Hydrazine-sensitive thiol protecting group for peptide and protein chemistry. ORGANIC LETTERS 13, 568-571, 2011.

13.Xiao B, Gong TJ, Xu J, Liu ZJ, Liu L.* Palladium-catalyzed intermolecular directed C-H amidation of aromatic ketones. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 133, 1466-1474, 2011.