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Yue Zhou


Yue Zhou


Email: Yue_Zhouatpkudotedudotcn


Research Area:

My overarching research interests focus on the role of epigenetic regulation in plant development and plant-environment responses. In addition to transcription factors, chromatin modifier complexes are also involved in gene regulation, and thereby provide another layer of gene transcription control. However, the function and molecular mechanisms underlying these epigenetic processes are poorly understood. We use a combined genetics, genomics, cell biology and biochemistry approaches to study how cis-elements and trans-acting factors cooperate to regulate chromatin modifications, gene transcription and ultimately plant development. We are also interested in the process of how chromatin status affects gene regulation under cold conditions (especially vernalization).


Selected Publications:

1.      Zhou, Y., Wang, Y., Krause, K., Dogus, J., Zhang, Y., Turck, F. Telobox motifs recruit CLF/SWN-PRC2 for H3K27me3 deposition via TRB factors in Arabidopsis. Nat Genet 50(5):638-644, doi:10.1038/s41588-018-0109-9 (2018).

2.      Cui H*., Qiu J*., Zhou Y., Bhandari D.D., Zhao C., Bautor J., and Parker J.E. Antagonism of transcription factor MYC2 by EDS1/PAD4 complexes bolsters salicylic acid defense in Arabidopsis effector-triggered immunity. Mol. Plant 11(8):1053-1066, doi: 10.1016/j.molp.2018.05.007 (2018).

3.     Zhou, Y., Tergemina, E., Cui, H., Forderer, A., Hartwig, B., Velikkakam James, G., Schneeberger, K., and Turck, F. Ctf4-related protein recruits LHP1-PRC2 to maintain H3K27me3 levels in dividing cells in Arabidopsis thaliana. Proc Natl Acad Sci U S A 114, 4833-4838, doi:10.1073/pnas.1620955114 (2017).

4.     Zhou, Y*., Romero-Campero, F.J*., Gomez-Zambrano, A., Turck, F., and Calonje, M. H2A monoubiquitination in Arabidopsis thaliana is generally independent of LHP1 and PRC2 activity. Genome Biol 18, 69, doi:10.1186/s13059-017-1197-z (2017).

5.     Merini, W., Romero-Campero, F.J., Gomez-Zambrano, A., Zhou, Y., Turck, F., and Calonje, M.. The Arabidopsis Polycomb Repressive Complex 1 (PRC1) Components AtBMI1A, B, and C Impact Gene Networks throughout All Stages of Plant Development. Plant physiology 173, 627-641, doi:10.1104/pp.16.01259 (2017).

6.     Zhou, Y., Hartwig, B., James, G. V., Schneeberger, K. & Turck, F. Complementary Activities of TELOMERE REPEAT BINDING Proteins and Polycomb Group Complexes in Transcriptional Regulation of Target Genes. The Plant Cell 28, 87-101, doi:10.1105/tpc.15.00787 (2016).

7.     Zhou, Y., Zhang, J., Lin, H., Guo, G. & Guo, Y. MORPHEUS' MOLECULE1 is required to prevent aberrant RNA transcriptional read-through in Arabidopsis. Plant physiology 154, 1272-1280, doi:10.1104/pp.110.162131 (2010). 

8.     Zhou, Y., Yang, Z., Guo, G. & Guo, Y. Microfilament dynamics is required for root growth under alkaline stress in Arabidopsis. Journal of integrative plant biology 52, 952-958, doi:10.1111/j.1744-7909.2010.00981.x (2010).


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