刘 磊

 

E-mail：lliu(at)mail(dot)tsinghua(dot)edu(dot)cn

Tel：+86-10-62780027

 

研究领域:

1. 蛋白质的化学合成与生物医学应用

2. 生物活性小分子的催化合成及应用

 

代表性科研论文：

1.Yiming Li, Maiyun Yang, Yichao Huang, Xiaoda Song, Lei Liu* and Peng R. Chen*. Genetically encoded alkenyl–pyrrolysine analogues for thiol–ene reaction mediated site-specific protein labeling. Chem. Sci., 2012, 3, 2766–2770

2.Ge-Min Fang.; Jia-Xing Wang.; Lei Liu*. Convergent Chemical Synthesis of Proteins by Ligation of Peptide Hydrazides. Angew. Chem. Int. Ed. 2012, 51, 10347-10350.

3.Yi-Ming Li, Mai-Yun Yang, Yi-Chao Huang, Yi-Tong Li, Peng R. Chen,* and Lei Liu*, Ligation of Expressed Protein -Hydrazides via Genetic Incorporation of an -Hydroxy Acid. ACS Chem. Biol. 2012, 7, 1015−1022

4.Ji-Shen Zheng; Shan Tang; Ye Guo; Hao-Nan Chang; Lei Liu*. Synthesis of Cyclic Peptides and Cyclic Proteins via Ligation of Peptide Hydrazides. ChemBioChem 2012, 13, 542–546.

5.Chu-Ting Yang, Zhen-Qi Zhang, Jun Liang, Jing-Hui Liu, Xiao-Yu Lu, Huan-Huan Chen, Lei Liu*, Copper-Catalyzed Cross-Coupling of Nonactivated Secondary Alkyl Halides and Tosylates with Secondary Alkyl Grignard Reagents. J. Am. Chem. Soc. 2012, 134, 11124−11127

6.Fang GM, Li YM, Shen F, Huang YC, Li JB, Lin Y, Cui HK, Liu L.* Protein chemical synthesis via ligation of peptide hydrazides. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50, 2011, in press.

7.Zheng JS, Chang HN, Wang FL, Liu L.* Fmoc synthesis of peptide thioesters without post-chain assembly manipulation. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 133, 2011, in press.

8.Gong TJ, Xiao B, Liu ZJ, Wan J, Xu J, Luo DF, Fu Y, Liu, L.* Rhodium-catalyzed selective C-H activation/olefination of phenol carbamates. ORGANIC LETTERS 13, 3235-3237, 2011.

9.Xiao B, Gong TJ, Liu ZJ, Liu JH, Luo DF, Xu J, Liu L.* Synthesis of dibenzofurans via palladium-catalyzed phenol-directed C-H activation/C-O cyclization. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 133, 9250-9253, 2011.

10.Yang CT, Zhang ZQ, Liu YC, Liu L.* Copper-catalyzed cross-coupling reaction of organoboron compounds with primary alkyl halides and pseudohalides. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50, 3904-3907, 2011.

11.Shang R, Ji DS, Chu L, Fu Y, Liu L.* Synthesis of a-aryl nitriles through palladium-catalyzed decarboxylative coupling of cyanoacetate salts with aryl halides and triflates. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50, 4470-4474, 2011.

12.Shen F, Zhang ZP, Li JB, Lin Y, Liu L.* Hydrazine-sensitive thiol protecting group for peptide and protein chemistry. ORGANIC LETTERS 13, 568-571, 2011.

13.Xiao B, Gong TJ, Xu J, Liu ZJ, Liu L.* Palladium-catalyzed intermolecular directed C-H amidation of aromatic ketones. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 133, 1466-1474, 2011.