生命科学联合中心

刘颖

电子邮件: ying.liu(at)pku(dot)edu(dot)cn；

实验室网页：http://www.yinglab.org

研究方向:

课题组现阶段的研究工作围绕细胞稳态调控，主要集中于线粒体应激的分子机制研究以及细胞在营养物质匮乏时的应激性代谢调控机制。

线粒体是细胞内的重要器官。它不仅为细胞提供能量，同时也参与许多信号传导通路和细胞凋亡过程。实验室以线虫为模式动物，希望从机体、组织和细胞等多层面深入理解线粒体损伤是如何被感知并进而启动相应的保护和修复机制的。线粒体损伤是衰老的重要诱因之一。因此，对线粒体监察的研究不仅将揭示线粒体损伤修复的调控机制，也将为衰老相关疾病的治疗提供靶向基因。

此外，课题组也以哺乳动物细胞和线虫为模型，结合生物化学、遗传学和细胞生物学的手段，希望解析机体感知营养物质和能量状态的分子机制。对该过程的研究将会对肥胖、糖尿病以及癌症等发病机制的理解起到促进作用。

代表性科研论文:

1. Gao K, Li Y, Hu SM and Liu Y*. SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension. eLife (2019) e41792

2. Ma C, Niu R, Huang T, Shao LW, Peng Y, Ding W, Wang Y, Jia G, He C, Li CY, He A and Liu Y*. N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation. Nature Cell Biology (2018) doi: 10.1038/s41556-018-0238-5.

3. Chen J, Ou Y, Yang Y, Li W, Xu Y, Xie Y and Liu Y*. KLHL22 activates amino-acid-dependent mTORC1 signaling to promote tumorigenesis and ageing. Nature 557(2018) 585-589.

4. Chen J^#, Ou Y^#, Li Y, Hu S, Shao LW and Liu Y*. Metformin Extends C. elegansLifespan through Lysosomal Pathway. eLife 6 (2017) e31268.

5. Shao LW, Niu R and Liu Y*. Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response. Cell Res. 11 (2016) 1182-1196. (cover story)

6. Berendzen K, Durieux J, Shao L, Tian Y, Kim H, Wolff S, Liu Y and Dillin A. Neuroendocrine coordination of mitochondrial stress signaling and proteostasis. Cell 166 (2016) 1553-1563.

7. Liu Y, Samuel B, Breen P, and Ruvkun G. Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature 508 (2014) 406-410.

8. Liu Y, Tan H, Tian H, Liang C, Chen S and Liu Q. Autoantigen La promotes efficient RNAi, antiviral response and transposon silencing by facilitating multiple-turnover RISC catalysis. Mol. Cell 44 (2011) 502-508.

9. Ye X^*, Huang N^*, Liu Y, Paroo Z, Huerta C, Li P, Chen S, Liu Q and Zhang H. Structure of C3PO and mechanism of Human RISC activation. Nat. Struct. Mol. Biol. 18 (2011) 650-657.

10. Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch L, Grishin N, Liu Q. C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Science 5941 (2009) 750-753.