姚 骏
Email: jyao@mail.tsinghua.edu.cn, yaojun_ca@hotmail.com
实验室主页：http://yaola
研究方向
我们的研究兴趣集中于神经疾病和突触信号传导。
在突触前神经末梢，通过突触小泡与质膜的的融合，小泡中贮存的神经递质以不同方式释放出来，并对突触后细胞乃至神经网络的活动产生多个层次的影响。同时，突触小泡的循环利用保证了神经递质能够持续稳定地释放。这两者的改变会导致突触可塑性变化的产生。利用分子遗传、神经电生理和荧光成像技术，我们致力于阐明突触小泡循环利用的分子机制和不同形式神经递质释放的深层分子机制。
大量的研究表明突触信号传导的缺陷存在于很多神经系统疾病中，比如精神分裂症和双极性躁郁症。诱导多能干细胞技术已经成为研究神经疾病的强大工具，甫一诞生便得到迅速的应用。在研究复杂的多基因疾病方面，这项技术尤其具有不可替代的优势，因为源自病人的功能细胞携带了该疾病的全部遗传信息。利用诱导多能干细胞技术，我们研究多种神经心理学疾病（精神经分裂症、双极性躁郁症、抑郁症）中的致病机理及突触生理在疾病中的改变与相关机制。
代表性论文
1. Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames TJ, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Ødegaard KJ, McCarthy MJ, Zandi PP, PBDS, Mi S, Brennand KJ, Kelsoe JR, Gage FH, Yao J (2015). Differential Responses to Lithium in Hyperexcitable Neurons from Bipolar Patients. Nature. (In Press)
2. Yu DX, Di Giorgio DP, Yao J, Marchetto MC, Brennand K, Wright R, Mei A, McHenry L, Lisuk D, Grasmik J, Silberman P, Silberman G, Jappelli R, Gage FH (2014). Modeling hippocampal neurogenesis using human pluripotent stem cells. Stem Cell Reports. 2014 Feb 27;2(3):295-310. doi: 10.1016/j.stemcr.2014.01.009. eCollection 2014 Mar 11.
3. Yao J, Kwon SE, Gaffaney JD, Dunning FM, Chapman ER (2012). Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles. Nature Neuroscience. 15(2): 243-249.
4. Yao J, Gaffaney JD, Kwon SE, Chapman ER (2011). Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release. Cell. 147(3):666-77.
5. Yao J, Mu Y, Gage FH (2012). Neural stem cells: mechanisms and modeling. Protein & Cell. 3(4): 251-261. (Review)
6. Wu Y, Gu Y, Morphew MK, Yao J, YehFL, Dong M, Chapman ER (2012). All three components of the neuronal SNARE complex contribute to secretory vesicle docking in PC12 cells. Journal of Cell Biology. 198(3):323-30.
7. Yeh FL, Dong M, Yao J, Tepp WH, Lin G, Johnson EA, Chapman ER (2010). SV2 mediates entry of tetanus neurotoxin into central neurons. PLoS Pathogens. 6(11): e1001207.
8. Yuan X, Yao J, Norris D, Tran DD, Bram RJ, Chen G, Luscher B (2008). Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors. Molecular and Cellular Neuroscience. 38(2):277-289.
9. Deng, L.*, Yao, J.*, Fang, C., Dong, N., Luscher, B., Chen G (2007). Sequential postsynaptic maturation governs the temporal order of GABAergic and glutamatergic synaptogenesis in rat embryonic cultures. Journal of Neuroscience. 27(40):10860-9. (*Equal contribution)
10. Yao, J., Qi, J. S., and Chen, G (2006). Actin-dependent activation of presynaptic silent synapses contributes to long-term synaptic plasticity in developing hippocampal neurons. Journal of Neuroscience. 26(31):8137-47.
11. Qi, J., Yao, J., Fang, C., Luscher, B., and Chen G (2006). Downregulation of Tonic GABA Currents Following Epileptogenic Stimulation of Rat Hippocampal Cultures. Journal of Physiology. 577(2): 579-590.