生命科学联合中心

吴虹

电子邮件：hongwu(at)pku(dot)edu(dot)cn;
电话：+86-10-62768720

研究方向
吴虹教授是北京大学讲席教授，生命科学学院院长。吴虹教授近20年的研究重点在于探讨抑癌基因PTEN在肿瘤发生，发展及耐药中的分子机制，并取得了一系列重要的研究成果，迄今已发表研究论文150余篇，引用21700多次。她所领导的团队第一个证实PTEN在调节组织干细胞G0-G1细胞周期进入，自我更新、增殖和存活中的重要作用并将PTEN对组织干细胞的调控作用与癌症干细胞的形成联系起来。吴虹教授近期工作主要集中于研究肿瘤细胞干性获得与维持机制并寻找抑制细胞分化的关键功能分子及信号通路，研究结果可以用于肿瘤分子水平上的分类与治疗，对于肿瘤的精准治疗有重大的理论和实际意义。

代表性科研论文

1. Ruscetti, M., Dadashian, E.L., Guo, W., Quach, B., Mulholland D.J., Park J.W., Tran, L.M., Kobayashi, N., Bianchi-Frias, D., Nelson, P.S., Xing, Y. and Wu, H.. (2015) HDAC Inhibition Impedes Epithelial-Mesenchymal Plasticity and Suppresses Metastatic, Castration-Resistant Prostate Cancer. Oncogene 2015 Dec 7. 4
2. Ruscetti, M., Quach, B., Dadashian, E.L., Mulholland, D.J. and Wu, H. (2015) Tracking and functional characterization of EMT and mesenchymal-like tumor cells in prostate cancer metastasis. Cancer Res. 2015 Jul;75 (13): 2749-59.
3. Schubbert S, Cardenas A, Chen H, Garcia C, Guo W, Bradner JE, Wu H. (2014) Targeting the MYC and PI3K pathways eliminates leukemia-initiating cells in T cell acute lymphoblastic leukemia. Cancer Res. 74：7048-59.
4. Mulholland, D., Kobayashi, N., Ruscetti, M., Zhi, A., Tran, L.M., Huang, J., Gleave, M and Wu, H (2012) Pten loss and RAS/MAPK activation coorperate to promote EMT and prostate cancer metastasis initiated from stem/progenitor cells. Cancer Res. 72 (7):1878-89.
5. Mulholland, D., Tran, M.L., Cai, H., Morim, A., Wang, S., Plaisier, S., Huang, J., Garraway, I., Graeber, T. and Wu, H. (2011) Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell 19, 792-804.
6. Guo, W., Lasky, J, Chang, C., Mosessian, S., Lewis, X., Xiao, Y., Yeh, J., Chen, J., Iruela-Arispe, L., Varella-Garcia, M. and Wu, H. (2008) Multi-genetic events collaboratively to Pten-null leukaemia stem-cell formation. Nature 453: 529-533.
7. Wang, S., Gao, J., Lei, Q-Y., Rozengurt, N., Pritchard, C., Jiao, J., Thomas, G., Li, G., Roy-Burman, P., Nelson, P., Liu, X., and Wu, H. (2003) Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell 4:209-221.
8. Groszer, M., Erickson, R., Scripture-Adams, D., Lesche, R., Trumpp, A., Zack, J., Kornblum, H., Liu, X., and Wu, H. (2001) Negative Regulation of Neural Stem/Progenitor Cell Proliferation by the Pten Tumor Suppressor Gene In Vivo. Science 294: 2186-2189.
9. Sun, H., Lesche, R., Li, DM., Liliental, J., Zhang, H., Gao, J., Garvarina, N., Mueller, B., Liu, X. and Wu, H. (1999) PTEN Modulates Cell Cycle Prograssion and Cell Survival by Regulating PIP3 and AKT/PKB Signaling Pathway. Proc. Natl. Acad. Sci. USA 96: 6199-6204.