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刘锦涛

刘锦涛


实验室电话:010-62791229

邮箱:JintaoLiu@tsinghua.edu.cn

 

研究方向:

刘锦涛课题组主要从事细菌生物被膜(bacterial biofilm)方面的研究。菌膜是由紧密排列的细菌形成的群落。它们导致许多病菌感染,并对药物及人体免疫系统有超强的抵抗力,这为治疗细菌感染提出了很大的挑战。本课题组使用交叉学科及定量的研究方法,致力于开发创新的菌膜培养及观测技术,研究菌膜的群体行为及时空动态特性,并寻找治疗细菌感染的有效途径。

 

代表性科研论文: 

1. Lee DD, Prindle A, Liu J, Süel GM. Snapshot: Electrochemical Communication in Biofilms. Cell 170, 214 (2017).

2. Liu J, Martinez-Corral R, Prindle A, Lee DD, Larkin J, Gabalda-Sagarra M, Garcia-Ojalvo J, Süel GM. Coupling between distant biofilms and emergence of nutrient time-sharing. Science 356, 638 (2017).

3. Humphries J, Xiong L, Liu J, Prindle A, Yuan F, Tsimring L, Süel GM. Species-independent attraction to biofilms through electrical signaling. Cell 168, 200 (2017).

4. Mugler A, Kittisopikul M, Hayden L, Liu J, Wiggins CH, Süel GM, Walczak AM. Noise expands the response range of the Bacillus subtilis competence circuit. PLoS Computational Biology 12(3): e1004793 (2016).

5. Prindle A, Liu J, Asally M, Ly S, Garcia-Ojalvo J, Süel GM. Ion channels enable electrical communication in bacterial communities. Nature 527, 59 (2015).

6. Liu J, Prindle A, Humphries J, Gabalda-Sagarra M, Asally M, Lee DD, Ly S, Garcia-Ojalvo J, Süel GM. Metabolic co-dependence gives rise to collective oscillations within biofilms. Nature 523, 550 (2015).

7. Setlow P, Liu J, Faeder JR. Heterogeneity in bacterial spore populations. In Bacterial Spores: Current Research and Applications. Editor: Ernesto Abel-Santos. Caister Academic Press (2012).

8. Yi X*, Liu J*, Faeder JR, Setlow P. Synergism between different germinant receptors in the germination of Bacillus subtilis spores. Journal of Bacteriology 193, 4664 (2011). (* co-first author)

9. Liu J, Faeder JR, Camacho CJ. Toward a quantitative theory of intrinsically disordered proteins and their function. Proceedings of the National Academy of Sciences USA 106, 19819 (2009).

10. Goldschmidt YY, Liu J. Langevin dynamics of the two-stage melting transition of vortex matter in Bi2Sr2CaCu2O8 in the presence of straight or tilted columnar defects. Physical Review B 76, 174508 (2007).

11. Avraham N, Goldschmidt YY, Liu J, Myasoedov Y, Rappaport M, Zeldov E, van der Beek CJ, Konczykowski M, Tamegai T. Dynamic and thermodynamic properties of porous vortex matter in Bi2Sr2CaCu2O8 in an oblique magnetic field. Physical Review Letters 99, 087001 (2007).

12. Qing Chen, Yi Wang, Liu J, Ke-Lin Wang. N-player quantum minority game. Physics Letters A 327, 98 (2004).


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