李磊

 

电子邮箱：lei.li@pku.edu.cn

研究领域：植物生物学

 

 

研究方向:

围绕microRNA基因网络的构建分析，阐明植物如何对内源信号和外源刺激协同应答以实现最优化生长，并据此改良作物性状。在模式植物拟南芥中整合转录因子染色质免疫沉淀测序数据、microRNA基因启动子分析、microRNA靶基因谱，构建转录因子-microRNA-靶基因网络。结合分子遗传学、细胞生物学、基因组学、数学建模等研究手段，解析以microRNA为中心的调控网络，加深和拓展对植物microRNA调控范畴的认知。通过诠释转录、转录后水平基因调控的有机耦合，阐明microRNA在植物生长发育与环境适应中广泛而重要的作用。同时结合比较基因组学和分子遗传学，旨在证明microRNA基因多样化、特异性地整合到基因调控网络之中的机制，是植物遗传多态性和表型多样化的一个重要成因，为生物多样性资源在农业上的应用提供新的思路。

 

  

代表性科研论文:

1.Zhang H, Zhao X, Li J, Cai C, Deng X, Li L* (2014) MicroRNA408 is critical for the HY5-SPL7 gene network that mediates the coordinated response to light and copper. Plant Cell 26: 4933-4953.

2.Zhang H, Li L* (2013) SQUAMOSA Promoter Binding Protein-Like7 regulated microRNA408 is required for vegetative development in Arabidopsis. Plant J 74: 98-109.

3.Yang X, Zhang H, Li L* (2012) Alternative mRNA processing increases the complexity of microRNA-based gene regulation in Arabidopsis. Plant J 70: 421-431.

4.Yang X, Li L* (2011) miRDeep-P: a computational tool for analyzing the microRNA transcriptome in plants. Bioinformatics 27: 2614-2615.

5.Li L*, Wang X, Stolc V, Li X, Zhang D, Su N, Tongprasit W, Li S, Cheng Z, Wang J, Deng X (2006) Genome-wide transcription analyses in rice using tiling microarrays. Nat Genet 38: 124-129.

6.Li L*, He H, Zhang J, Wang X, Bai S, Stolc V, Tongprasit W, Young ND, Yu O, Deng X (2008) Transcriptional analysis of highly syntenic regions between Medicago truncatula and Glycine max using tiling microarrays. Genome Biol 9: R57.

7.Li L*, Wang X, Xia M, Stolc V, Su N, Peng Z, Li S, Wang J, Wang X, Deng X (2005) Tiling microarray analysis of rice chromosome 10 to identify the transcriptome and relate its expression to chromosomal architecture. Genome Biol 6: R52.