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唐淳

 

 

唐淳

 

EmailTang_Chun_AT_pku.edu.cn
课题组网站:http://www.tanglab.org


研究方向:

 

1.发展核磁方法,重点关注顺磁核磁的原子分子探针开发,更好表征蛋白质、RNA等生物大分子的动态结构和瞬态相互作用

2.发展整合结构生物学的计算方法,联合运用小角散射、单分子荧光、质谱交联等技术,发展质谱交联数据的定量优化方法

3.研究化学修饰对生物大分子动态结构的调控作用,重点关注泛素的磷酸化及 RNA的m6A甲基化的影响

 

代表性文章: 

 

1.        Tang C, Gong Z. (2020) Integrating Non-NMR Distance restraints to augment NMR depiction of protein structure and dynamics. J Mol Biol, doi: 10.1016/j.jmb.2020.01.023

2.        Tang C, Zhang WP. (2020) How phosphorylation by PINK1 remodels the ubiquitin system, a perspective from structure and dynamics. Biochemistry, 59:26-33

3.        You ZY, Jiang WX, Qin LY, Gong Z, Wan W, Li J, Wang YS, Zhang HT, Peng C, Zhou TH, Tang C, Liu W. (2019) Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress. Nat Commun, 10:5792

4.        Huang JB, Dong X, Gong Z, Qin LY, Yang S, Zhu YL, Wang X, Zhang DL, Zou TT, Yin P, Tang C. (2019) Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. Protein Cell, 10:272-284

5.        Gong Z, Yang S, Yang QF, Zhu YL, Jiang J, Tang C. (2019) Refining RNA solution structures with the integrative use of label-free paramagnetic relaxation enhancement NMR. Biophys Rep, 5:244-253

6.        Gong Z, Charles DS, Tang C (2018) Theory and practice of using solvent paramagnetic relaxation enhancement to characterize protein conformational dynamics. Methods, 148:48-56

7.        Liu Z, Gong Z, Cao Y, Ding YH, Dong MQ, Lu YB, Zhang WP, Tang C. (2018). Characterizing protein dynamics with integrative use of bulk and single-molecule techniques. Biochemistry, 57:305-313

8.        Ding YH, Gong Z, Dong X, Liu K, Liu Z, Liu C, He SM, Dong MQ, Tang C. (2017). Modeling protein excited-state structures from "over-length" chemical cross-links. J Biol Chem, 292:1187-1196

9.        Jiang WX, Gu XH, Dong X, Tang C. (2017). Lanthanoid tagging via an unnatural amino acid for protein structure characterization. J Biomol NMR, 67:273-282

10.     Dong X, Gong Z, Lu YB, Liu K, Qing LY, Ran ML, Zhang CL, Liu Z, Zhang WP, Tang C. (2017). Ubiquitin S65 phosphorylation engenders a pH-sensitive conformational switch. Proc Natl Acad Sci, USA, 114:6770-6775

11.     Gong Z, Gu XH, Guo DC, Wang J, Tang C. (2017). Protein structural ensembles visualized by solvent paramagnetic relaxation enhancement. Angew Chem Int Ed, 56:1002-1006

12.     Liu Z, Gong Z, Dong X, Tang C. (2016) Transient protein-protein interactions visualized by solution NMR. BBA Proteins and Proteomics, 1864:115-122

13.     Liu Z, Gong Z, Jiang WX, Yang J, Zhu WK, Guo DC, Zhang WP, Liu ML, Tang C. (2015) Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition. eLife, 4:e05767

14.     Gong Z, Charles DS, Tang C. (2015) Conjoined use of EM and NMR in RNA structure refinement. Plos One, 10, e0120445

15.     Xing Q, Huang P, Yang J, Sun JQ, Gong Z, Dong X, Guo DC, Chen SM, Yang YH, Wang Y, Yang MH, Yi M, Ding YM, Liu ML, Zhang WP, Tang C. (2014) Visualizing an ultra-weak protein-protein interaction in phosphorylation signaling. Angew Chem Int Ed, 53:11501-11505

 

 

 

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