Li WU

Email: wuli@tsinghua.edu.cn

Telephone: +86-10-62794835

Research Area：

1.Molecular regulation of innate immune cell development and differentiation

2.Homeostatic regulation of the ocular immune system and immunological mechanisms of related diseases

3.Mechanistic studies on the regulation of tumor immune responses by innate immune cells

Selected Publications:

1. Liu JC,Ma J,Yao JY,Y Z,Wang YH,Yang CY,Li X, Xing NZ,Zhu YP,Zhang JH,Wu L. High-resolution transcriptome atlas of bladder cancer highlights the functional myeloid subsets in modulating immune microenvironment. eBioMedicine 2025 Volume117

2. Shen XY , Li XG, Guo TT, Wu T, Lv JY , He ZM , Luo MC , Zhu XY , Tian YJ, Lai WL , Dong C , Hu XY and Wu L.TRIM33 plays a critical role in regulating dendritic cell differentiation and homeostasis by modulating Irf8 and Bcl2l11 transcription.Cellular & Molecular Immunology; 2024 https://doi.org/10.1038/s41423-024-01179-1.

3. Zhou HB and Wu L.Cancer cells reprogrammed into dendritic cells in vivo promote  antitumor immunity.science.2024,VOL 386 ISSUE 6719 10.1126/science.ads6761.

4. Tian YJ, Guo XH, Wu T, Fei KY, Wu L. Identification of a novel cDC2-committed progenitors within mouse common dendritic cell progenitor population. Protein & Cell, 2022, https://doi.org/10.1007/s13238-021-00902-2.

5. Proietto AI, Mittag D, Roberts AW, Sprigg N,Wu L. The equivalents of human blood and spleen dendritic cell subtypes can be generated in vitro from human CD34+ stem cells in the presence of fms-like tyrosine kinase 3 ligand and thrombopoietin. Cell & Mol. Immunol. 2012,9, 446–454. SCI.

6. Zhan YF,Wu L. Functional regulation of monocyte-derived dendritic cells by microRNAs.Protein & Cell. 2012, 3(7): 497–507. SCI.

7. Sathe P, Vremec D, Wu L, Corcoran L, Shortman K. Convergent differentiation: myeloid and lymphoid pathways to murine plasmacytoid dendritic cells. Blood. 2012. Oct 10. doi:10.1182/blood-2012-02-413336.

8. Carotta S, Dakic A, D’Amico A, Pang SHM, Greig KT, Nutt SL,Wu L. The Transcription Factor PU.1 Controls Dendritic Cell Development and Flt3 Cytokine Receptor Expression in a Dose Dependent Manner. Immunity 28:628-41, 2010

9. Proietto AI, van Dommelen S, Zhou P, Rizzitelli A, D'Amico A, Steptoe RJ, Naik SH, Lahoud MH, Liu Y, Zheng P, Shortman K and Wu L. Dendritic cells in the thymus contribute to T-regulatory cell induction. Proceedings of The National Academy of Sciences USA 105:19869-19874, 2008.

10. Naik SH, Sathe P, Park H-Y, Metcalf D, Anna I. Proietto AI, Dakic A, Carotta S, O’Keeffe M, Bahlo M, Papenfuss A, Kwak J-Y, Wu L, Shortman K. Development of plasmacytoid and conventional dendritic cell subtypes from single in vitro and in vivo-derived precursors. Nature Immunology 8:1217, 2007.

11. Wu L,Liu YJ. The Development of Dendritic Cell Lineages. Immunity. 26:741-750. 2007.

12. Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, Wu L, Lindeman GJ, & Visvader JE. Generation of a functional mammary gland from a single stem cell. Nature 439:84-88. 2006.

13. Wu L, D’Amico A, Winkel K.D, Suter M, Lo D, Shortman K. RelB is essential for the development of Myeloid-related CD8a- dendritic cells but not of lymphoid-related CD8a+ dendritic cells. Immunity, 9:839-847, 1998.

14. Ardavin C, Wu L, Li C-L, Shortman K. Thymic dendritic cells and T cells develop simultaneously within the thymus from a common precursor population. Nature 362: 761-763, 1993.

15. Wu L, Scollay R, Egerton M, Pearse M, Spangrude GJ, Shortman K. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature 349: 71-74, 1991.