Name：Huji Xu

Research Area:

1、 The pathogenesis of autoimmune diseases

2、 Immunogenetics

3、 Vaccine research

Selected Publications:

1. Wu X, Chen H, Xu H. The genomic landscape of human immune-mediated diseases. J Hum Genet. 2015;60(11):675-81

2. Okada Y, Wu D, Trynka G, Towfique Raj, Terao Chikashi, Ikari Katsunori, Kochi Yuta, Ohmura Koichiro, Suzuki Akari, Yoshida Shinji, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye LY, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Mirel TD, Stahl EA, Esko D, Metspalu A, Zhou X, Namrata Gupta,´e Diogo, Cui J, Liao K, Guo MH, Myouzen K, Takahisa K, Coenen MJ, Piet L. C. M. van Riel, Mart A. F. J. van de Laar, Guchelaar HJ, Huizinga TW, Dieude P, Mariette X,S. Louis Bridges Jr, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Solbritt Rantapa¨a¨-Dahlqvist, Lisbeth A rlestig, Choi HK, Kamatani Y, Galan P, Lathrop M, the RACI consortium, the GARNET consortium, Eyre S, Bowes J, Barton A, Niek de Vries, Moreland LW, Criswell LA, Karlson1 EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, De Jager P, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K & Plenge RM. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature.2014;506:376-81

3. Jiang L, Yin J, Ye L, Yang J, Hemani G, Liu A, Zou H, He D, Sun L, Zeng X, Li Z, Zheng Y, Lin Y, Liu Y, Fang Y, Xu J, Li Y, Dai S, Guan J, Jiang L, Wei Q, Wang Y, Li Y, Huang C, Zuo X, Liu Y, Wu X, Zhang L, Zhou L, Zhang Q, Li T, Chen L, Xu Z, Yang X, Qian F, Xie W, Liu W, Guo Q, Huang S, Zhao J, Li M, Jin Y, Gao J, Lv Y, Wang Y, Lin L, Guo A, Danoy P, Willner D, Cremin C, Hadler J, Zhang F, Zhao Y, Li M, Yue T, Fan X, Guo J, Mu R, Li J, Wu C, Zeng M, Wang J, Li S, Jin L, Wang B, Wang J, Ma X, Sun L, Zhang X, Brown MA, Visscher PM, Su D, Xu H. Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans. Arthritis & Rheumatism.2014;66:1121-32

4. International Genetics of Ankylosing Spondylitis Consortium (IGAS), Spondyloarthritis Research Consortium of Canada (SPARCC), Wellcome Trust Case Control Consortium 2 (WTCCC2). Idendification of multiple risk variants for ankylosing spondylitits through high-density genotyping of immune–related loci. Nat Genet.2013;45:730-8

5. Davidson SI, Jiang L, Cortes A, Wu X, Glazov EA, Zheng Y, Danoy PA, Liu Y, Thomas GP, Brown MA, Xu H. High-throughput sequencing of IL23R reveals a low-frequency, nonsynonymous single-nucleotide polymorphism that is associated with ankylosing spondylitis in a Han Chinese population. Arthritis Rheum.2013;65:1747-52

6. Danoy P, Wei M, Johanna H, Jiang L, He D, Sun L, Zeng X, Visscher PM, Brown MA, Xu H. Association of variants in MMEL1 and CTLA4 with rheumatoid arthritis in the Han Chinese population. Ann Rheum Dis.2011;70:1793-1797

7. Davidson SI, Liu Y, Danoy PA, Wu X, Thomas GP, Jiang L, Sun L, Wang N, Han J, Han H, Visscher PM, Brown MA, Xu H. Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese. Ann Rheum Dis.2011;70: 289-92

8. Xu H, Wipasa J, Yan H, Zeng M, Makobongo MO, Finkelman FD, Kelso A, Good MF. The mechanism and significance of deletion of parasite-specific CD4(+) T cells in malaria infection. J Exp Med.2002;195: 881-92