Fan Bai

Email:fbai(at)pku(dot)edu(dot)cn

Tel: +86-10-62756164

Research area：

We innovate and develop multidisciplinary integrated methods, including single-molecule fluorescence imaging, single-cell sequencing, and bioinformatics analysis, to investigate the pathogenic mechanisms of clinically complex diseases and explore novel therapeutic strategies. Our recent research has focused on: 1) somatic mutations present in normal human tissues and their role in tumorigenesis; 2) circulating tumor cells and multi-organ metastasis in cancer; 3) elucidating the pathogenic mechanisms of pediatric immune diseases at single-cell resolution; and 4) the molecular mechanisms underlying antibiotic bactericidal action and bacterial drug resistance.

Selected Publications:

1. Gao Y#, Peng Y#, Cheng J#, Zhang X#, Zhong J, Lu C, ......, Liu X, Xiao F, Wang X, Bai F*, Zhang N*, Meningeal blood vessel blockage enhances anti-glioblastoma immunity, Cell 189 (2026), 1305-1322.

2. Xing X#, Zhong J#, Biermann J#, Duan H#, Zhang X#, Shi Y#, ……, Mou Y*, Izar B*, Zhang N*, Bai F*, Pan-cancer human brain metastases atlas at single-cell resolution, Cancer Cell 43 (2025), 1242-1260

3. Li F#, Xing X#, Jin Q#, ……, Yu C*, Chen L*, Bai F*, Gao D*, Sex differences orchestrated by androgens at single-cell resolution, Nature 629 (2024), 193-200

4. Chen L#, Zhang C#, Xue R#, ……, Wu L*, Rozen SG*, Bai F*, Wang H*, Deep whole genome analysis of 494 hepatocellular carcinomas, Nature 624 (2024), 586-593

5. Li R#, Di L#, Li J#, ……, Lin D*, Huang Y*, Wang J*, Bai F*, Wu C*, A body map of somatic mutagenesis in morphologically normal human tissues, Nature 597 (2021), 398-403

6. Li R#, Du Y#, Chen Z#, ……, Xu T*, Bai F*, Macroscopic somatic clonal expansion in morphologically normal human urothelium, Science 370 (2020), 82-89

7. Huang B#, Chen Z#, Geng L#, ......, Gong S*, Bai F*, Yang M*, Zhang Y*, Mucosal profiling of pediatric-onset colitis and IBD reveals common pathogenics and therapeutic pathways, Cell 179 (2019), 1160-1176

8. Pu Y#, Li Y#, Jin X#, ……, Lo CJ, Bai F*, ATP-dependent dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic tolerance, Molecular Cell 73 (2019), 1-14

9. Pu Y#, Zhao Z#, Li Y#, ……, Xie XS*, Bai F*, Enhanced efflux activity facilitates drug tolerance in dormant bacterial cells, Molecular Cell 62 (2016), 284-294

10. Bai F#, Branch R#, Nicolau D#,……, Berry R*, Conformational spread as a mechanism for cooperativity in the bacterial flagellar switch, Science 327 (2010), 685-689