生命科学联合中心
学术报告
题 目：基因组时代的脑网络组研究
报告人：蒋田仔
中国科学院自动化研究所，研究员
时 间：2012年12月13日（星期四）下午1：00-2：00
地 点：北京大学新生物楼邓祐才报告厅
联系人：生命科学联合中心 张小明 (Tel. 6275-8144)
Convergent evidence has shown that the psychiatric diseases are faulty brain networks. In order to understand the pathophysiological mechanism of psychiatric disorders, it is necessary to integrate the multi-level network features obtained with various functional and anatomical brain imaging technologies on different scales. On macroscale, such features can be obtained from networks based on illness special region of interest, networks related to specific cognitive function, and whole brain networks. We have proposed a new concept of “Brainnetome” to represent such integration framework. We define the essential components of Brainnetome as network topological structure (connectome), performance, dynamics, manifestation of functions and malfunctions of brain on different scales, genetic basis of brain networks, and simulating and modeling brain networks on supercomputing facilities. This lecture will cover the above aspects of brainnetome. We first give a brief review about why Brainnetome is needed. Then functional brain networks based on resting-state functional MRI will be discussed in detail. After that, brain networks based on diffusion MRI will be presented. We will also present some new findings on abnormalities of functional connectivity and networks of human brain with neurological and psychiatric diseases, especially Alzheimer's Diseases, Schizophrenia. Finally, some perspective and future research directions will be touched. It envisions that Brainnetome will become an emerging co-frontier of brain imaging, information technology, neurology and psychiatry. Some long-standing issues in neuropsychiatry may be solved by combining Brainnetome with genome.
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