第三十九期水木清华生命科学讲座系列
裴端卿，1965年出生于湖北荆州，1984年毕业于华中农学院，1991年获得美国宾夕法尼亚大学分子细胞与发育专业博士学位，现任中国科学院广州生物医药与健康研究院院长，教授。
在美国期间曾从事乙肝病毒转录调控研究和基质金属蛋白酶与肿瘤侵蚀转移关系的研究，回国后研究开始研究干细胞，发现并阐明维生素C促进诱导多能干细胞形成机理；发现并阐明间充质向上皮细胞转换（MET)启动诱导多能干细胞形成机制；并将人体尿液上皮细胞直接转换为不含外源基因并可移植的神经干细胞，有望用于神经损伤与退行性疾病治疗。裴端卿于2013年度获国家自然科学二等奖，2009和2014年二次获得广东省科技一等奖，2014年获谈家桢创新奖，2010年入选十大国内科技新闻。曾担任十一五863计划生物医药领域专家和国家重大科学研究计划《干细胞研究》专家组召集人之一。目前为国家科技重点研究计划《干细胞及其转化研究》专家。
Topic：Cell Fate Decision: Mechanism and Application
Speaker:
Duanqing PEI, Ph.D.
Director General (President)
Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, in Guangzhou, China.
Abstract:
My long-term interest is to understand how cell fate is controlled. Recently, we have been employing the reprogramming system, i.e., the conversion of somatic cells such as MEFs into pluripotent stem cells or iPSCs. The advantage of this system is that all 4 factors, Oct4, Sox2, Myc and Klf4 are transcription factors evolved to regulate pluripotency, metabolism, carcinogenesis, but in combination can achieve a seemingly impossible fete, i.e., converting a fully differentiated cell to a state only found in blastocysts. So, there may be a lot of unknown secrets associated with this remarkable process. Over the past 10 years, we have uncovered that a mesenchymal to epithelial transition (MET) initiates the reprogramming process and Vitamin C (Vc), known for its anti-scurvy activity and required for human health, promotes the generation of iPSCs by activating both histone and DNA demethylases. Most recently, we have uncovered a second route to pluripotency which appears to be in parallel to the one defined by Yamanaka in 2006. The new route is guarded by cJun and requires 6 factors of which 3 were defined in our own lab. Implication of this new route as well as their practical applications will be discussed.
时间：2016年3月10日 15:00 - 16:00
地点：医学科学楼B323
