第五十三期水木清华生命科学讲座系列
黄岩谊，1997年获北京大学化学专业理学学士学位，2002年获北京大学无机化学专业理学博士学位；2002-2006年在美国加州理工学院应用物理系、斯坦福大学生物工程系从事博士后研究工作；2006年回到北京大学工作。现任北京大学工学院材料科学与工程系教授，北京大学生物动态光学成像中心研究员，北京大学北京未来基因诊断高精尖创新中心研究员，北京大学-清华大学生命科学联合中心研究员，北京大学化学与分子工程学院兼职教授。近几年来，黄岩谊课题组主要从事新型基因组测序技术、大规模微流控芯片技术和无标记显微成像技术的研究。
Topic:Accurately Assessing Genomic Heterogeneity in Complex Biosystems - from Bulk to Single Cells
Speaker:
Yanyi Huang, Professor
Peking University
Abstract:
Biosystems are intrinsically heterogeneous. Conventional ensemble measurements heavily rely on ‘average’ values from multiple experimental replicates to study the quantitative difference between samples, or between conditions. However, the heterogeneity at the cellular level make such strategy impossible in many cases. Next generation sequencing technologies allow us to obtain large and informative data-set with relatively low cost and high throughput, and become the key driving force to facilitate our understanding of complex biosystems. However, prevalent methods are still problematic when handle highly heterogeneous samples because of the mix of real biological variations and technical variations or noises. I am going to present recent technology developments in my group, mostly the combination usage of microscopic imaging with microfluidics, to facilitate the approaches using next generation sequencing tools to analyze small number of cells or even single cells.
日期：4月6日（周四）15:00-16:00
地点：清华大学医学科学楼B323
