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7月20日清华大学生物论坛 - Andrzej Wierzbicki
发布时间:2017-07-13关键字:

The Role of RNA Polymerase V and Its Transcripts

 

 

Andrzej Wierzbicki, Ph.D.

Associate Professor,

University of Michigan,

Department of Molecular,

Cellular and Developmental Biology


Biography:

Andrzej Wierzbicki obtained his PhD from the University of Warsaw, Poland and was a postdoctoral fellow with Craig Pikaard at Washington University in St. Louis. In 2009 he started his group at the University of Michigan, Ann Arbor, where he is now an Associate Professor.


Abstract:

RNA-directed DNA methylation is a conserved process where small RNAs target transposons and other sequences for repression by establishing chromatin modifications. A central element of this process is long noncoding RNA (lncRNA) which has been proposed to serve as a binding scaffold for small RNAs and associated proteins. In Arabidopsis thaliana, this lncRNA is produced by a specialized RNA polymerase known as Pol V. Pol V transcripts serve as a binding scaffold for several RNA-binding proteins, which mediate the recruitment of chromatin modifying enzymes. These enzymes contribute to the repression of transposon activity and help determine the boundaries between heterochromatic transposons and their euchromatic environment. RNA-directed DNA methylation has also been implicated in controlling organization of chromosomes, which may explain how it affects expression of distant genes. 


 

Time: July. 20th, 2017,16:00-17:00

Venue: New Biology Building, Room 143

Host: Prof. Yijun Qi

举办单位:生命科学联合中心

 




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