U6 snRNP biogenesis and Structure
Prof. Samuel E. Butcher PhD
Department of Biochemistry,
University of Wisconsin-Madison,
433 Babcock Drive,
Madison, Wisconsin 53706-15445
Biography：
Prof. Samuel received his B.S. degree from University of California, Davis in 1989; After he was awarded the Ph.D. diploma in Microbiology and Molecular Genetics, University of Vermont, Burlington in 1995, he joined the Department of Chemistry and Biochemistry, University of California at Los Angeles as a Postdoctoral Fellow. In 2000, he moved to Department of Biochemistry, University of Wisconsin-Madison as a assistant professor, and then was promoted to associate professor in 2005. He was awarded Shaw Scientist Award in 2002 and Pound Research Award in 2007 from university of Wisconsin-Madison. In 2010, he became the Professor of Department of Biochemistry. In 2016, he was awarded the CALS Spitzer Teaching Award from university of Wisconsin-Madison.
Abstract：
Precursor mRNA splicing is catalyzed by the spliceosome and is a crucial step in gene expression. The spliceosome active site contains the U6 small nuclear RNA, which must undergo a complex biogenesis pathway before it can be incorporated into the spliceosome. This biogenesis pathway involves a series of molecular transformations, including post-transcriptional RNA modification and large-scale conformational changes involving many different proteins. I will describe our recent progress towards understanding the U6 small nuclear ribonucleoprotein particle (U6 snRNP) biogenesis pathway and will discuss how it relates to human disease and evolution. Finally, I will present the structure of the U6 snRNP, which was recently solved in my laboratory.
Time: April. 3rd, 2018, 10:30-11:30
Venue: New Biology Building, Room 143
Host: Prof. Xianyang Fang
举办单位：生命科学联合中心
